2. Gene
  3. NELL2 - neural EGFL like 2 Gene

NELL2 - neural EGFL like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经 EGFL 样 2

种属: Homo sapiens

同用名: NRP2

基因 ID: 4753 | 基因类型: protein coding

关于 NELL2

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:44,508,275-44,921,848 (from NCBI)

This gene has 20 transcripts (splice variants), 240 orthologues and 1 paralogue. Biased expression in brain (RPKM 55.4), duodenum (RPKM 9.0) and 5 other tissues.

功能概要

该基因编码的蛋白质是一种糖蛋白，包含多个 von Willebrand 因子 C 结构域和表皮生长因子 (EGF) 样结构域。编码的蛋白质充当同源三聚体，存在于细胞质中。存在编码几种不同异构体的几种变体，并且至少一种异构体似乎是一种分泌蛋白。对小鼠的研究表明，这种蛋白质在神经细胞生长和分化以及肿瘤发生中发挥作用。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

NELL2 基因产物(5)

mRNA Protein Name
NM_001145107.2 NP_001138579.1 protein kinase C-binding protein NELL2 isoform a
NM_001145108.2 NP_001138580.1 protein kinase C-binding protein NELL2 isoform b precursor
NM_001145109.2 NP_001138581.1 protein kinase C-binding protein NELL2 isoform c precursor
NM_001145110.2 NP_001138582.1 protein kinase C-binding protein NELL2 isoform d
NM_006159.2 NP_006150.1 protein kinase C-binding protein NELL2 isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
32198364 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
32198364 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in commissural neuron axon guidance IMP
IMP: 通过突变表型推断
32198364 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NELL2 蛋白结构

Laminin_G_2

Laminin_G_2: Laminin G domain (96 - 210)

VWC

VWC: von Willebrand factor type C domain (274 - 330)

EGF_CA

EGF_CA: Calcium-binding EGF domain (440 - 473)

EGF_CA

EGF_CA: Calcium-binding EGF domain (484 - 521)

cEGF

cEGF: Complement Clr-like EGF-like (578 - 605)

VWC

VWC: von Willebrand factor type C domain (705 - 755)

  • 0
  • 200
  • 400
  • 600
  • 816 a.a.
蛋白主名 其他名称

protein kinase C-binding protein NELL2

NEL-like protein 2

NELL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NELL2 Q99435 NUFIP2 Homo sapiens Q7Z417
Y2H Pooling
21653829
种属内
NELL2 Q99435 NUFIP2 Homo sapiens Q7Z417
Anti Tag CoIP
21653829
种属内
NELL2 Q99435 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
21653829
种属内
NELL2 Q99435 SHANK3 Homo sapiens Q9BYB0
Y2H Pooling
21653829
种属内
NELL2 Q99435 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
种属内
NELL2 Q99435 HOXA1 Homo sapiens P49639
Anti Tag CoIP
21653829
种属内
NELL2 Q99435 MBD1 Homo sapiens Q9UIS9
Anti Tag CoIP
21653829
种属内
NELL2 Q99435 MBD1 Homo sapiens Q9UIS9
Y2H Pooling
21653829
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NELL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75936 NELL2 Protein, Human (sf9, His) Q99435 (L22-L816) ≥95%

关联疾病

疾病名称 别名
Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma
Childhood Ependymoma
Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Posterior Fossa Ependymoma
Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord

Spinal Ependymoma

Ependymoma Of Spinal Cord
Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma
High Grade Ependymoma

Ependymal Neoplasm

Ependymal Tumors

Malignant Ependymoma

Ependymal Tumor

Anaplastic Ependymoma

Experimental Organism Malignant Ependymoma

Ependymoma Of Brain
Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms

Cerebral Ventricle Neoplasm

Intraventricular Tumor Of Brain
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09205 NELL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NELL2 MGD MGI:1858510
Rattus norvegicus NELL2 RGD RGD:620999
Macaca mulatta NELL2 VGNC VGNC:75313
Canis familiaris NELL2 VGNC VGNC:43740
Bos taurus NELL2 VGNC VGNC:32003
Felis catus NELL2 VGNC VGNC:68461
Others NELL2 NCBI
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