1. Gene
  2. NOP2 - NOP2 nucleolar protein Gene

NOP2 - NOP2 nucleolar protein Gene

中文名称:NOP2 核仁蛋白

种属: Homo sapiens

同用名: NOL1; p120; NSUN1; NOP120

基因 ID: 4839 | 基因类型: protein coding

关于 NOP2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,556,871-6,568,291 (from NCBI)

This gene has 23 transcripts (splice variants), 171 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 12.9), bone marrow (RPKM 12.9) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与细胞群增殖的正调控; p53 类介质调节信号转导;和核糖体大亚基组装。位于核仁。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Involved in positive regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; and ribosomal large subunit assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

NOP2 基因产物(5)

mRNA Protein Name
NM_001033714.3 NP_001028886.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1
NM_001258308.2 NP_001245237.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 2
NM_001258309.2 NP_001245238.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 3
NM_001258310.2 NP_001245239.1 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 4
NM_006170.4 NP_006161.2 probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12080348 GOA
enables rRNA (cytosine-C5-)-methyltransferase activity IDA
IDA: 通过直接分析推断
26196125 GOA
enables rRNA (cytosine-C5-)-methyltransferase activity IMP
IMP: 通过突变表型推断
36161484 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
1394192 GOA
involved in rRNA processing IDA
IDA: 通过直接分析推断
36161484 GOA
involved in regulation of signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
24120868 GOA
involved in ribosomal large subunit assembly IMP
IMP: 通过突变表型推断
24120868 GOA
involved in ribosomal large subunit biogenesis IDA
IDA: 通过直接分析推断
36161484 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
8089149 GOA
located in nucleus IDA
IDA: 通过直接分析推断
36161484 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NOP2 蛋白结构

Methyltr_RsmB-F

Methyltr_RsmB-F: 16S rRNA methyltransferase RsmB/F (300 - 585)

P120R

P120R: P120R (NUC006) repeat (623 - 644)

P120R

P120R: P120R (NUC006) repeat (683 - 705)

P120R

P120R: P120R (NUC006) repeat (749 - 768)

  • 0
  • 200
  • 400
  • 600
  • 812 a.a.
蛋白主名 其他名称

probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

NOL1/NOP2/Sun domain family, member 1

NOP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NOP2 P46087 MT1F Homo sapiens P04733
Validated Y2H
25416956
Intra NOP2 P46087 MT1F Homo sapiens P04733
Y2H Prey Pooling
25416956
Intra NOP2 P46087 RBM28 Homo sapiens Q9NW13
Anti Tag CoIP
33961781
Intra NOP2 P46087 KPNA6 Homo sapiens O60684
Validated Y2H
25416956
Intra NOP2 P46087 CDCA7L Homo sapiens Q96GN5
Validated Y2H
25416956
Intra NOP2 P46087 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra NOP2 P46087 NIP7 Homo sapiens Q9Y221
Anti Tag CoIP
33961781
Intra NOP2 P46087 NIP7 Homo sapiens Q9Y221
Anti Tag CoIP
35271311
Intra NOP2 P46087 NIP7 Homo sapiens Q9Y221
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dubowitz Syndrome

Dubowitz'S Syndrome

Dwarfism-Eczema-Peculiar Facies Syndrome

Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy

B-All With Hyperdiploidy

B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy

Cardiomyopathy, Familial Restrictive, 1

RCM1

Restrictive Cardiomyopathy 1

Rcm

Familial Restrictive Cardiomyopathy 1

Cardiomyopathy, Familial Restrictive 1

Cardiomyopathy, Restrictive, Familial, Type 1

Rcm-1

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NOP2 RGD RGD:1304616
Macaca mulatta NOP2 VGNC VGNC:75365
Mus musculus NOP2 MGD MGI:107891
Felis catus NOP2 VGNC VGNC:106435
Canis familiaris NOP2 VGNC VGNC:43889
Bos taurus NOP2 VGNC VGNC:32167