2. Gene
  3. NPY5R - neuropeptide Y receptor Y5 Gene

NPY5R - neuropeptide Y receptor Y5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经肽 Y 受体 Y5

种属: Homo sapiens

同用名: NPYR5; NPY5-R; NPYY5-R

基因 ID: 4889 | 基因类型: protein coding

关于 NPY5R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues. Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues.

功能概要

该基因编码的蛋白质是神经肽 Y 和肽 YY 的受体。编码的蛋白质似乎与调节食物摄入有关，该基因的缺陷与饮食失调有关。此外，编码的蛋白质参与保护神经母细胞瘤细胞免受化学疗法诱导的细胞死亡的途径，从而提供针对神经母细胞瘤的可能治疗靶点。已发现该基因的三个转录变体编码相同的蛋白质。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

NPY5R 基因产物(3)

mRNA Protein Name
NM_001317091.2 NP_001304020.1 neuropeptide Y receptor type 5
NM_001317092.2 NP_001304021.1 neuropeptide Y receptor type 5
NM_006174.4 NP_006165.1 neuropeptide Y receptor type 5
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac left ventricle morphogenesis IMP
IMP: 通过突变表型推断
19593212 GOA
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19593212 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPY5R 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 5

NPY-Y5 receptor

关联疾病

疾病名称 别名
Dihydropyrimidinase Deficiency

Dihydropyrimidinuria

Dpys Deficiency

Dph Deficiency

DPYSD

Dihydrouracil Amidohydrolase Deficiency

Dihydropyrimidinuria Due To Dpys Deficiency
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107734 L 152804 Antagonist 99.48% 否
HY-RS09520 NPY5R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NPY5R VGNC VGNC:54273
Mus musculus NPY5R MGD MGI:108082
Bos taurus NPY5R VGNC VGNC:32224
Rattus norvegicus NPY5R RGD RGD:3199
Felis catus NPY5R VGNC VGNC:68539
Macaca mulatta NPY5R VGNC VGNC:75395
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z