2. Gene
  3. NUCB2 - nucleobindin 2 Gene

NUCB2 - nucleobindin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核结合蛋白 2

种属: Homo sapiens

同用名: NEFA; HEL-S-109

基因 ID: 4925 | 基因类型: protein coding

关于 NUCB2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,276,739-17,349,980 (from NCBI)

This gene has 19 transcripts (splice variants), 279 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues.

功能概要

该基因编码的蛋白质在钙水平维持、下丘脑进食调节和血管内皮细胞释放肿瘤坏死因子方面具有建议的作用。这种蛋白质结合钙并具有 EF 折叠结构域。[RefSeq 提供，2011 年 10 月]

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

NUCB2 基因产物(14)

mRNA Protein Name
NM_001330227.3 NP_001317156.1 nucleobindin-2 isoform 2 preproprotein
NM_001352661.2 NP_001339590.1 nucleobindin-2 isoform 3 preproprotein
NM_001352662.2 NP_001339591.1 nucleobindin-2 isoform 4 preproprotein
NM_001352663.2 NP_001339592.1 nucleobindin-2 isoform 3 preproprotein
NM_001352664.2 NP_001339593.1 nucleobindin-2 isoform 1 preproprotein
NM_001352665.2 NP_001339594.1 nucleobindin-2 isoform 2 preproprotein
NM_001352666.2 NP_001339595.1 nucleobindin-2 isoform 2 preproprotein
NM_001352667.2 NP_001339596.1 nucleobindin-2 isoform 2 preproprotein
NM_001352668.2 NP_001339597.1 nucleobindin-2 isoform 1 preproprotein
NM_001352669.2 NP_001339598.1 nucleobindin-2 isoform 1 preproprotein
NM_001352670.2 NP_001339599.1 nucleobindin-2 isoform 1 preproprotein
NM_001352671.2 NP_001339600.1 nucleobindin-2 isoform 2 preproprotein
NM_001352672.2 NP_001339601.1 nucleobindin-2 isoform 1 preproprotein
NM_005013.4 NP_005004.1 nucleobindin-2 isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sequestering of metal ion EXP
EXP: 通过实验结果推断
32184136 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
15308636 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUCB2 蛋白结构

EF-hand_7

EF-hand_7: EF-hand domain pair (248 - 321)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
蛋白主名 其他名称

nucleobindin-2

DNA-binding protein NEFA

NUCB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NUCB2 P80303 GADD45A Homo sapiens P24522
Y2H
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NUCB2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71177 Nucleobindin-2 Protein, Human P80303-1 (V25-L106) ≥95%

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09655 NUCB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NUCB2 RGD RGD:620888
Bos taurus NUCB2 VGNC VGNC:32319
Mus musculus NUCB2 MGD MGI:1858179
Felis catus NUCB2 VGNC VGNC:68587
Macaca mulatta NUCB2 VGNC VGNC:75549
Canis familiaris NUCB2 VGNC VGNC:44020
Others NUCB2 NCBI
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