2. Gene
  3. Adam8 - ADAM metallopeptidase domain 8 Gene

Adam8 - ADAM metallopeptidase domain 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 8

种属: Rattus norvegicus

同用名: RGD1566394

基因 ID: 499285 | 基因类型: protein coding

关于 Adam8

Primary_assembly 1: 194,770,060-194,788,801 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 245 orthologues, 29 paralogues and is associated with 7 phenotypes. Biased expression in Lung (RPKM 68.), Spleen (RPKM 32.8) and 8 other tissues.

功能概要

预测该基因编码的蛋白能使细胞粘附分子结合的活性；金属离子结合活性；和金属肽酶活性。预计参与多个过程，包括白细胞迁移；白细胞迁移的正向调节；和大分子代谢过程的正向调控。预测作用于细胞-细胞粘附的上游或内部。预计位于多个细胞成分中，包括细胞表面；细胞质囊泡；和足体。预计是质膜的组成部分。预计是 alpha9-beta1 整合素-ADAM8 复合物的一部分。与人类 ADAM8（ADAM 金属肽酶结构域 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cell adhesion molecule binding activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in several processes, including leukocyte migration; positive regulation of leukocyte migration; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Predicted to be integral component of plasma membrane. Predicted to be part of alpha9-beta1 integrin-ADAM8 complex. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8). [provided by Alliance of Genome Resources, Apr 2022]

Adam8 基因产物(8)

mRNA Protein Name
XM_006230499.4 XP_006230561.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X1
XM_006230501.4 XP_006230563.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X7
XM_017590243.2 XP_017445732.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X6
XM_039101260.1 XP_038957188.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X4
XM_039101261.1 XP_038957189.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X5
XM_039101259.1 XP_038957187.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X3
XM_006230500.4 XP_006230562.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X2
XM_039101262.1 XP_038957190.1 disintegrin and metalloproteinase domain-containing protein 8 isoform X8

Adam8 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: pfam01562 (27 - 151)

Reprolysin

Reprolysin: pfam01421 (195 - 394)

DISIN

DISIN: smart00050 (411 - 485)

ACR

ACR: smart00608 (487 - 606)

PHA03247

PHA03247: cl33720 (735 - 863)

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  • 868 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 8

a disintegrin and metallopeptidase domain 8

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120852 JG26 Inhibitor 98.01% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adam8 NCBI NCBI:101
Mus musculus Adam8 NCBI NCBI:11501
Macaca mulatta Adam8 NCBI NCBI:100428452
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