P2RY2 - purinergic receptor P2Y2 Gene

中文名称：嘌呤能受体 P2Y2

种属: Homo sapiens

同用名: P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R

关于 P2RY2

功能概要

该基因的产物属于 P2 受体家族，由细胞外核苷酸激活，细分为 P2X 配体门控离子通道和 P2Y G 蛋白偶联受体。该家族有几种具有不同药理学选择性的受体亚型，在某些情况下，它们对各种腺苷和尿苷核苷酸有重叠。这种受体存在于许多细胞类型中，被 ATP 和 UTP 激活，据报道在某些癌细胞类型中过度表达。它参与许多细胞功能，例如增殖、凋亡和炎症。已经为该基因鉴定了编码相同蛋白质的三个转录物变体。[RefSeq 提供，2013 年 3 月]

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some Cancer cell types. It is involved in many cellular functions, such as proliferation, Apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]