PA2G4 - proliferation-associated 2G4 Gene

中文名称：增殖相关 2G4

种属: Homo sapiens

同用名: EBP1; HG4-1; p38-2G4

关于 PA2G4

功能概要

该基因编码一种参与生长调节的 RNA 结合蛋白。该蛋白存在于前核糖体核糖核蛋白复合物中，可能参与核糖体组装和 rRNA 加工的中间和后期步骤的调节。这种蛋白质可以与 ErbB3 受体的细胞质结构域相互作用，并可能有助于转导生长调节信号。通过与组蛋白脱乙酰酶的相互作用，该蛋白质还是雄激素受体调节基因和其他细胞周期调节基因的转录共阻遏物。这种蛋白质与人类癌细胞的生长抑制和分化诱导有关。已经鉴定出位于染色体 3、6、9、18、20 和 X 上的六个假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human Cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]