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  3. Pde3a - phosphodiesterase 3A Gene

Pde3a - phosphodiesterase 3A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 3A

种属: Rattus norvegicus

同用名: RNPDE3A

基因 ID: 50678 | 基因类型: protein coding

关于 Pde3a

Primary_assembly 4: 174,172,868-174,438,274 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 258 orthologues, 20 paralogues and is associated with 10 phenotypes. Biased expression in Heart (RPKM 245.3), Lung (RPKM 86.5) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动 3',5'-环状 AMP 磷酸二酯酶活性。参与细胞凋亡过程的负调控；负调节 cAMP 介导的信号；和卵母细胞的成熟。位于胞质溶胶中。肥胖和肺动脉高压的生物标志物。该基因的人类直系同源物与高血压和短指综合征有关。与人 PDE3A（磷酸二酯酶 3A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of apoptotic process; negative regulation of cAMP-mediated signaling; and oocyte maturation. Located in cytosol. Biomarker of obesity and pulmonary hypertension. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]

Pde3a 基因产物(1)

mRNA Protein Name
NM_017337.1 NP_059033.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
15867171 RGD
involved in negative regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
9884079 RGD
involved in oocyte maturation IEP
IEP: 通过表达模式推断
11673261 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde3a 蛋白结构

PDEase_I

PDEase_I: pfam00233 (750 - 1011)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1141 a.a.
蛋白主名 其他名称

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

CGI-PDE A

cyclic GMP-inhibited phosphodiesterase A

cyclic nucleotide phosphodiesterase

phosphodiesterase 3A, cGMP inhibited

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-U00186 K134 Inhibitor 99.84% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101312 Cilostamide Inhibitor 99.64% 否
HY-W028690 DNMDP Inhibitor 98.95% 否
HY-100530C Sp-cAMPS sodium salt 99.45% 否
HY-136350 BRD9500 Modulator 99.46% 否
HY-122751 (R)-DNMDP Inhibitor 99.59% 否
HY-100530B Sp-cAMPS / 否
HY-136350B (S)-BRD9500 99.67% 否
HY-162730 OPB-171775 Inhibitor 99.80% 否
HY-110005 Sp-cAMPS triethylamine / 否
HY-153802 Antitumor agent-100 Inducer / 否
HY-153802A Antitumor agent-100 hydrochloride Inducer / 否
HY-N10149 Nauclefine / 否
HY-N11965 4'-Methoxyisoagarotetrol Inhibitor / 否
HY-RS10216 PDE3A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10217 Pde3a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10218 Pde3a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde3a NCBI NCBI:5139
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