Sp-cAMPS 

Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC₅₀ of 40 μM^[1][2][3].

Sp-cAMPS 是腺苷环状 3',5'-硫代磷酸酯的刺激性非对映异构体，其处理肝细胞，模拟胰高血糖素所见的反应。Sp-cAMPS 可以模拟胰高血糖素刺激的 Ca²⁺ 水平升高^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在慢性饮酒 (CAC) 小鼠中，将 Sp-cAMPS (1 µg/µL) 直接注入前额叶皮层可显着改善孤僻动物，或损害水生动物的工作记忆表现^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

345.27

C₁₀H₁₂N₅O₅PS

71774-13-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31.  [Content Brief]

  [2]. L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5.  [Content Brief]

  [3]. Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9.  [Content Brief]

  [4]. P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.  [Content Brief]

  [5]. G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77.  [Content Brief]