2. Gene
  3. HP1BP3 - heterochromatin protein 1 binding protein 3 Gene

HP1BP3 - heterochromatin protein 1 binding protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：异染色质蛋白 1 结合蛋白 3

种属: Homo sapiens

同用名: HP1BP74; HP1-BP74

基因 ID: 50809 | 基因类型: protein coding

关于 HP1BP3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,740,266-20,787,307 (from NCBI)

This gene has 14 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in thyroid (RPKM 36.6), endometrium (RPKM 35.9) and 25 other tissues.

功能概要

启用 DNA 结合活性和核小体结合活性。参与多个过程，包括细胞对缺氧的反应；异染色质组织；和核大小的调节。位于染色体和核斑点。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and nucleosome binding activity. Involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Located in chromosome and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

HP1BP3 基因产物(16)

mRNA Protein Name
NM_001372052.1 NP_001358981.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376787.1 NP_001363716.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376788.1 NP_001363717.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376789.1 NP_001363718.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376790.1 NP_001363719.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376791.1 NP_001363720.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376792.1 NP_001363721.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376793.1 NP_001363722.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376794.1 NP_001363723.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376795.1 NP_001363724.1 heterochromatin protein 1-binding protein 3 isoform 3
NM_001376796.1 NP_001363725.1 heterochromatin protein 1-binding protein 3 isoform 3
NM_001376797.1 NP_001363726.1 heterochromatin protein 1-binding protein 3 isoform 4
NM_001399820.1 NP_001386749.1 heterochromatin protein 1-binding protein 3 isoform 5
NM_001399821.1 NP_001386750.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001399823.1 NP_001386752.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_016287.5 NP_057371.2 heterochromatin protein 1-binding protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
20042602 GOA
enables nucleosome binding IDA
IDA: 通过直接分析推断
20042602 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20042602 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
25100860 GOA
involved in heterochromatin organization IMP
IMP: 通过突变表型推断
24830416 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
24830416 GOA
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
24830416 GOA
involved in regulation of nucleus size IMP
IMP: 通过突变表型推断
24830416 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
20042602 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24830416 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HP1BP3 蛋白结构

Linker_histone

Linker_histone: linker histone H1 and H5 family (159 - 230)

Linker_histone

Linker_histone: linker histone H1 and H5 family (267 - 330)

Linker_histone

Linker_histone: linker histone H1 and H5 family (346 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
蛋白主名 其他名称

heterochromatin protein 1-binding protein 3

关联疾病

疾病名称 别名
Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type

Methylmalonic Acidemia Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

Methylmalonic Acidemia, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

Methylmalonic Aciduria Type Cblb

MMAB

Methylmalonic Aciduria Type B

Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

Aciduria, Methylmalonic, Cblb Type

Methylmalonic Acidemia

Methylmalonic Aciduria
Postpartum Depression

Maternity Blues

Postnatal Depression

Depression, Postpartum

Post-Partum Depression

Depression Postpartum
Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder
Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3

Cataract 34 Multiple Types

CTRCT34

Catc3

Cataract 34, Multiple Types, With Or Without Microcornea

Autosomal Recessive Congenital Cataract 3

Cataract 34 Multiple Types With Or Without Microcornea

Cataract, Multiple Types, Type 34
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06332 HP1BP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HP1BP3 VGNC VGNC:62835
Bos taurus HP1BP3 VGNC VGNC:29935
Mus musculus HP1BP3 MGD MGI:109369
Rattus norvegicus HP1BP3 RGD RGD:735099
Macaca mulatta HP1BP3 VGNC VGNC:73440
Canis familiaris HP1BP3 VGNC VGNC:41767
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