2. Gene
  3. TRAT1 - T cell receptor associated transmembrane adaptor 1 Gene

TRAT1 - T cell receptor associated transmembrane adaptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：T 细胞受体相关跨膜接头 1

种属: Homo sapiens

同用名: TRIM; TCRIM; HSPC062; pp29/30

基因 ID: 50852 | 基因类型: protein coding

关于 TRAT1

Cytogenetic location: 3q13.13 Genomic coordinates (GRCh38): 3:108,822,786-108,855,005 (from NCBI)

This gene has 5 transcripts (splice variants) and 113 orthologues. Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues.

功能概要

预测可启用跨膜受体蛋白酪氨酸激酶接头活性。在受体循环的负调节上游或负调节内起作用；运输的负面监管；和信号转导的正调控。位于中心卫星；有丝分裂纺锤体;和质膜。 T 细胞受体复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

TRAT1 基因产物(2)

mRNA Protein Name
NM_001317747.2 NP_001304676.1 T-cell receptor-associated transmembrane adapter 1 isoform 2
NM_016388.4 NP_057472.2 T-cell receptor-associated transmembrane adapter 1 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of receptor recycling IDA
IDA: 通过直接分析推断
11390434 GOA
acts upstream of or within negative regulation of transport IDA
IDA: 通过直接分析推断
11390434 GOA
acts upstream of or within positive regulation of T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
11390434 GOA
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: 通过直接分析推断
11390434 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of T cell receptor complex IDA
IDA: 通过直接分析推断
11390434 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11390434 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAT1 蛋白结构

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (12 - 121)

  • 0
  • 100
  • 186 a.a.
蛋白主名 其他名称

T-cell receptor-associated transmembrane adapter 1

T cell receptor interacting molecule

TRAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRAT1 Q6PIZ9 SEC22A Homo sapiens Q96IW7
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TRAT1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71379 TRAT1 Protein, Human (His) Q6PIZ9 (N29-N186) ≥95%

关联疾病

疾病名称 别名
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h

Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency

Muscular Dystrophy Hutterite Type

Sarcotubular Myopathy

Limb-Girdle Muscular Dystrophy Type 2h
Mulibrey Nanism

MUL

Muscle-Liver-Brain-Eye Nanism

Pericardial Constriction And Growth Failure

Perheentupa Syndrome

Mulibrey Growth Disorder

Mulibrey Nanism Syndrome

Pericardial Constriction With Growth Failure

Nanism Mulibrey
Inclusion Conjunctivitis

Chlamydial Conjunctivitis

Inclusion Blennorrhoea

Paratrachoma

Adult Inclusion Conjunctivitis

Inclusion Blenorrhea

Conjunctivitis, Inclusion

Neonatal Chlamydial Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Chronic Conjunctivitis Due To Chlamydia Trachomatis

Inclusion Conjunctivitis Due To Chlamydia Trachomatis

Acute Follicular Conjunctivitis, Chlamydial

Adult Chlamydial Keratoconjunctivitis
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14996 TRAT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRAT1 VGNC VGNC:79865
Rattus norvegicus TRAT1 RGD RGD:1563011
Canis familiaris TRAT1 VGNC VGNC:47789
Felis catus TRAT1 VGNC VGNC:102858
Mus musculus TRAT1 MGD MGI:1924897
Bos taurus TRAT1 VGNC VGNC:36295
Others TRAT1 NCBI
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