2. Gene
  3. SPOCK3 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 Gene

SPOCK3 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：SPARC (骨连蛋白) 、cwcv 和 kazal 样结构域蛋白聚糖 3

种属: Homo sapiens

同用名: TES-3; TICN3; HSAJ1454

基因 ID: 50859 | 基因类型: protein coding

关于 SPOCK3

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:166,733,384-167,234,945 (from NCBI)

This gene has 26 transcripts (splice variants), 190 orthologues and 3 paralogues. Biased expression in brain (RPKM 28.5), prostate (RPKM 28.2) and 2 other tissues.

功能概要

该基因编码一个新的钙结合蛋白聚糖蛋白家族的成员，该家族包含 1 型甲状腺球蛋白和 Kazal 样结构域。编码的蛋白质可能通过抑制膜型基质金属蛋白酶的活性在成人 T 细胞白血病中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type Matrix Metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

SPOCK3 基因产物(9)

mRNA Protein Name
NM_001040159.2 NP_001035249.1 testican-3 isoform 1 precursor
NM_001204352.2 NP_001191281.1 testican-3 isoform 3
NM_001204353.1 NP_001191282.1 testican-3 isoform 4
NM_001204354.2 NP_001191283.1 testican-3 isoform 5
NM_001204355.2 NP_001191284.1 testican-3 isoform 6
NM_001204356.2 NP_001191285.1 testican-3 isoform 7 precursor
NM_001204358.2 NP_001191287.1 testican-3 isoform 9 precursor
NM_001251967.2 NP_001238896.1 testican-3 isoform 11 precursor
NM_016950.3 NP_058646.2 testican-3 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metalloendopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
11751414 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of endopeptidase activity IDA
IDA: 通过直接分析推断
11751414 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
11751414 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
11751414 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPOCK3 蛋白结构

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (142 - 183)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (199 - 308)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (317 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

testican-3

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13697 SPOCK3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SPOCK3 RGD RGD:1305672
Canis familiaris SPOCK3 VGNC VGNC:54224
Felis catus SPOCK3 VGNC VGNC:107469
Mus musculus SPOCK3 MGD MGI:1920152
Macaca mulatta SPOCK3 VGNC VGNC:100272
Others SPOCK3 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z