GLRX2 - glutaredoxin 2 Gene

中文名称：谷氧还蛋白 2

种属: Homo sapiens

同用名: GRX2; CGI-133

关于 GLRX2

功能概要

由该基因编码的蛋白质是谷氧还蛋白家族的成员，它维持细胞硫醇稳态。这些蛋白质是硫醇二硫化物氧化还原酶，在其活性位点使用谷胱甘肽结合位点和一个或两个活性半胱氨酸。该基因经过选择性剪接产生多种同种型，其中一种广泛表达并定位于线粒体，在线粒体氧化还原稳态中发挥作用，对于防止氧化应激和从氧化应激中恢复非常重要。其他具有更多限制性表达模式的亚型显示细胞溶质和细胞核定位，并被认为在细胞分化和转化中起作用，可能在肿瘤进展中起作用。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]