NMD3 - NMD3 ribosome export adaptor Gene

中文名称：NMD3 核糖体输出适配器

种属: Homo sapiens

同用名: CGI-07

基因 ID: 51068 | 基因类型: protein coding

关于 NMD3

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:161,221,102-161,253,532 (from NCBI)

This gene has 10 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 18.0), urinary bladder (RPKM 15.3) and 25 other tissues.

功能概要

核糖体 40S 和 60S 亚基结合在核仁中并输出到细胞质。该基因编码的蛋白质参与 60S 亚基通过核孔复合体进入细胞质的过程。该基因存在多个转录本变体，但迄今为止仅描述了其中两个的全长性质。[RefSeq 提供，2016 年 2 月]

Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]

NMD3 基因产物(2)

mRNA	Protein	Name
NM_001320227.2	NP_001307156.1	60S ribosomal export protein NMD3 isoform 1
NM_015938.5	NP_057022.2	60S ribosomal export protein NMD3 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	12773398	GOA
enables ribosomal large subunit binding	IDA IDA: 通过直接分析推断	12773398	GOA
enables ribosomal large subunit binding	IPI IPI: 通过物理相互作用推断	12724356	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of RNA biosynthetic process	IMP IMP: 通过突变表型推断	23782956	GOA
involved in positive regulation of protein binding	IMP IMP: 通过突变表型推断	12724356	GOA
involved in positive regulation of protein localization to nucleolus	IMP IMP: 通过突变表型推断	23782956	GOA
involved in ribosomal large subunit export from nucleus	IMP IMP: 通过突变表型推断	12773398	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12724356	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	12773398	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	12773398	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NMD3 蛋白结构

NMD3

0
100
200
300
400
503 a.a.

蛋白主名

其他名称

60S ribosomal export protein NMD3

NMD3 homolog

关联疾病

疾病名称

别名

Retinitis Pigmentosa 34

RP34

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-149386	D3R/MOR antagonist 1	Antagonist	/	否
HY-149387	D3R/MOR antagonist 2	Antagonist	/	否
HY-RS09370	NMD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NMD3	VGNC	VGNC:32125
Mus musculus	NMD3	MGD	MGI:2140103
Canis familiaris	NMD3	VGNC	VGNC:43856
Macaca mulatta	NMD3	VGNC	VGNC:75242
Rattus norvegicus	NMD3	RGD	RGD:1308468
Felis catus	NMD3	VGNC	VGNC:63835

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NMD3 - NMD3 ribosome export adaptor Gene

关于 NMD3

功能概要

NMD3 基因产物(2)

NMD3 蛋白结构

关联疾病

直系同源

热门区域

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NMD3 - NMD3 ribosome export adaptor Gene

关于 NMD3

功能概要

NMD3 基因产物(2)

NMD3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z