VRK3 - VRK serine/threonine kinase 3 Gene

中文名称：VRK 丝氨酸/苏氨酸激酶 3

种属: Homo sapiens

关于 VRK3

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶的牛痘相关激酶 (VRK) 家族成员。在人类和小鼠中，该基因在 ATP 结合基序内的几个残基处发生了取代，这些基序在其他激酶中已被证明是催化所必需的。体外试验表明该蛋白质缺乏磷酸化活性。然而，该蛋白质可能保留其底物结合能力。该基因在人体组织中广泛表达，其蛋白质定位于细胞核。可变剪接导致多个转录本编码不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in Other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]