2. Gene
  3. SHISA5 - shisa family member 5 Gene

SHISA5 - shisa family member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：shisa 家族成员 5

种属: Homo sapiens

同用名: SCOTIN

基因 ID: 51246 | 基因类型: protein coding

关于 SHISA5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,467,876-48,504,810 (from NCBI)

This gene has 19 transcripts (splice variants), 121 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 49.3), spleen (RPKM 32.3) and 25 other tissues.

功能概要

该基因编码 shisa 家族的一个成员。编码的蛋白质定位于内质网，并与 p53 一起以 Caspase 依赖性方式诱导细胞凋亡。可变剪接导致多个转录本变体。在 X 染色体上发现了该基因的相关假基因。[RefSeq 提供，2016 年 4 月]

This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces Apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. Related pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Apr 2016]

SHISA5 基因产物(7)

mRNA Protein Name
NM_001272065.3 NP_001258994.1 protein shisa-5 isoform b precursor
NM_001272066.2 NP_001258995.1 protein shisa-5 isoform c
NM_001272067.2 NP_001258996.1 protein shisa-5 isoform c
NM_001272068.2 NP_001258997.1 protein shisa-5 isoform c
NM_001272082.4 NP_001259011.1 protein shisa-5 isoform d
NM_001272083.4 NP_001259012.1 protein shisa-5 isoform e
NM_016479.6 NP_057563.3 protein shisa-5 isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables WW domain binding IPI
IPI: 通过物理相互作用推断
15064722 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15064722 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SHISA5 蛋白结构

Shisa

Shisa: Wnt and FGF inhibitory regulator (27 - 209)

  • 0
  • 100
  • 200
  • 240 a.a.
蛋白主名 其他名称

protein shisa-5

putative NF-kappa-B-activating protein 120

SHISA5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
SHISA5 Q8N114 Pdcd6 Mus musculus P12815
Far-WB
17889823
种属间
SHISA5 Q8N114 Pdcd6 Mus musculus P12815
Pull Down
17889823
种属间
SHISA5 Q8N114 Pdcd6 Mus musculus P12815
Anti Tag CoIP
17889823
种属内
SHISA5 Q8N114 WWOX Homo sapiens Q9NZC7
Far-WB
15064722
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064
Microcephaly 6, Primary, Autosomal Recessive

MCPH6

Primary Autosomal Recessive Microcephaly 6

Microcephaly, Primary Autosomal Recessive, 6

Microcephaly, Type 6, Primary, Autosomal Recessive
Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C

FANCC

Facc

Fac

Fa3

Fanconi Pancytopenia Type 3

Fanconi Pancytopenia, Type 3

Faces Syndrome

Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

Friedman-Goodman Syndrome

Abnormality Of The Face
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12868 SHISA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SHISA5 VGNC VGNC:84082
Mus musculus SHISA5 MGD MGI:1915044
Canis familiaris SHISA5 VGNC VGNC:108258
Bos taurus SHISA5 VGNC VGNC:34601
Rattus norvegicus SHISA5 RGD RGD:1359661
Felis catus SHISA5 VGNC VGNC:80715
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