2. Gene
  3. BFAR - bifunctional apoptosis regulator Gene

BFAR - bifunctional apoptosis regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双功能凋亡调节因子

种属: Homo sapiens

同用名: BAR; RNF47

基因 ID: 51283 | 基因类型: protein coding

关于 BFAR

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:14,632,951-14,669,236 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele and 211 orthologues. Ubiquitous expression in placenta (RPKM 13.9), urinary bladder (RPKM 13.0) and 25 other tissues.

功能概要

启用半胱天冬酶结合活性；蛋白质-大分子衔接活性；和泛素蛋白连接酶活性。参与 IRE1 介导的未折叠蛋白反应的负调控；蛋白酶体介导的泛素依赖性蛋白质分解代谢过程；和蛋白质泛素化。在细胞凋亡过程的负调节上游或负调节中起作用。位于内质网和膜内。 [由基因组资源联盟提供，2022 年 4 月]

Enables Caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein Ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Apr 2022]

BFAR 基因产物(2)

mRNA Protein Name
NM_001330500.2 NP_001317429.1 bifunctional apoptosis regulator isoform 2
NM_016561.3 NP_057645.1 bifunctional apoptosis regulator isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables caspase binding IDA
IDA: 通过直接分析推断
10716992 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21068390 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
10716992 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
21068390 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of IRE1-mediated unfolded protein response IMP
IMP: 通过突变表型推断
21068390 GOA
acts upstream of or within negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
10716992 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
21068390 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
21068390 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
21068390 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
21068390 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
21068390 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
21068390 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
21068390 GOA
located in membrane IDA
IDA: 通过直接分析推断
10716992 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BFAR 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (34 - 73)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (181 - 247)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
蛋白主名 其他名称

bifunctional apoptosis regulator

RING finger protein 47

BFAR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BFAR Q9NZS9 UBE2K Homo sapiens P61086
Y2H Array
32814053
种属内
BFAR Q9NZS9 UBE2K Homo sapiens P61086
Validated Y2H
32814053
种属内
BFAR Q9NZS9 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Epulis

Epulides

Gingival Polyp

Polyp Of Gum
Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome

Spiegler-Brooke Syndrome

Familial Cylindromatosis

BRSS

Bss

Sbs

Multiple Familial Trichoepithelioma

Ancell-Spiegler Cylindromas

Familial Multiple Trichoepithelioma

Trichoepithelioma

Fc

Mft

Multiple Familial Trichoepitheliomas

Ccs

Turban Tumor Syndrome

Schilbach-Rott Syndrome

Eccrine Dermal Cylindroma

Familial Multiple Trichoepitheliomata
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-170393 iBFAR2 Inhibitor / 否
HY-RS01485 BFAR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta BFAR VGNC VGNC:70339
Felis catus BFAR VGNC VGNC:60106
Bos taurus BFAR VGNC VGNC:26477
Mus musculus BFAR MGD MGI:1914368
Canis familiaris BFAR VGNC VGNC:38439
Rattus norvegicus BFAR RGD RGD:1304791
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