2. Gene
  3. FKBP11 - FKBP prolyl isomerase 11 Gene

FKBP11 - FKBP prolyl isomerase 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FKBP 脯氨酰异构酶 11

种属: Homo sapiens

同用名: FKBP19

基因 ID: 51303 | 基因类型: protein coding

关于 FKBP11

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,921,963-48,939,034 (from NCBI)

This gene has 13 transcripts (splice variants), 199 orthologues and 18 paralogues. Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues.

功能概要

FKBP11 属于肽基-脯氨酰顺/反异构酶的 FKBP 家族，可催化含脯氨酸多肽的折叠。 FKBP 蛋白的肽基-脯氨酰异构酶活性被免疫抑制剂化合物 FK506 和雷帕霉素抑制 (Rulten 等人，2006 [PubMed 16596453]) 。[OMIM 提供，2008 年 3 月]

FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

FKBP11 基因产物(3)

mRNA Protein Name
NM_001143781.2 NP_001137253.1 peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2
NM_001143782.2 NP_001137254.1 peptidyl-prolyl cis-trans isomerase FKBP11 isoform 3 precursor
NM_016594.3 NP_057678.1 peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

FKBP11 蛋白结构

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (54 - 141)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase FKBP11

19 kDa FK506-binding protein

重组 FKBP11 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76344 FKBP11 Protein, Human (HEK293, Fc) Q9NYL4 (G28-G155) ≥95%

关联疾病

疾病名称 别名
Osteogenesis Imperfecta, Type V

Osteogenesis Imperfecta Type 5

OI5

Osteogenesis Imperfecta Type V

Oi Type 5

Oi Type V

Oi, Type V

Oi With Calcification In Interosseous Membranes

Type V Oi

Osteogenesis Imperfecta 5

Oi-V
Caffey Disease

Infantile Cortical Hyperostosis

CAFYD

Cortical Congenital Hyperostosis

Caffey-Silverman Syndrome

De Toni-Caffey Disease

Hyperostosis Cortical Infantile

Hyperostosis, Cortical, Congenital
Brittle Bone Disorder

Osteogenesis Imperfecta

Brittle Bone Disease

Fragilitas Ossium

Osteopsathyrosis

Lobstein Disease

Oi

Vrolik Disease

Lobstein'S Disease

Lobstein'S Syndrome

Vrolik'S Disease

Porak And Durante Disease

Glass Bone Disease

Osteogenesis Imperfecta, Dominant Perinatal Lethal

Osteogenesis Imperfecta, Recessive Perinatal Lethal

Brittle Bone Syndrome

Oi - [Osteogenesis Imperfecta]

Ossium Fragility

Osteitis Fragilitans

Bony Fragility

Blue Sclera With Fragility Of Bone And Deafness

White Blue Sclera - Fragility Of Bone - Deafness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04957 FKBP11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FKBP11 RGD RGD:1306161
Canis familiaris FKBP11 VGNC VGNC:40887
Felis catus FKBP11 VGNC VGNC:84020
Bos taurus FKBP11 VGNC VGNC:29018
Mus musculus FKBP11 MGD MGI:1913370
Others FKBP11 NCBI
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