FKBP11 蛋白, Human (HEK293, Fc)

The FKBP11 protein is a peptidyl prolyl cis-trans isomerase (PPIase) that plays a crucial role in accelerating protein folding, especially in complex protein synthesis. FKBP11 uses its enzymatic abilities to promote rapid and precise conformational changes that are critical for correct protein folding and maturation. FKBP11 Protein, Human (HEK293, Fc) is the recombinant human-derived FKBP11 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FKBP11 Protein, Human (HEK293, Fc) is 128 a.a., with molecular weight of ~40.4-45 KDa.

FKBP11 蛋白作为肽基-脯氨酰顺反异构酶 (PPIase) 处于中心地位，它在加速蛋白质折叠方面发挥着至关重要的作用，特别是在复杂的蛋白质合成环境中。FKBP11 利用其酶促能力，促进蛋白质正确折叠和成熟所需的快速而精确的构象变化。作为 PPIase 家族的一员，FKBP11 擅长催化脯氨酸酰亚胺肽键的顺反异构化，从而影响新生或错误折叠多肽的动态结构转变。这种功能属性强调了该蛋白质对维持细胞蛋白质稳态的重要贡献，暗示其对多种细胞过程的潜在影响。需要进一步探索，以揭示 FKBP11 在合成过程中积极参与复杂的蛋白质折叠过程的具体分子机制。

Specific activity is 3735.130 nmoL/min/mg, and is defined as the amount of enzyme that cleaves 1 nmole of suc-AAPF-pNA per minute at 37°C in Tris-HCl pH 8.0 using chymotrypsin.

Human

HEK293

C-mFc

Q9NYL4 (G28-G155)

51303  [NCBI]

GLETESPVRTLQVETLVEPPEPCAEPAAFGDTLHIHYTGSLVDGRIIDTSLTRDPLVIELGQKQVIPGLEQSLLDMCVGEKRRAIIPSHLAYGKRGFPPSVPADAVVQYDVELIALIRANYWLKLVKG

Approximately 40.4-45 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.