CHST15 - carbohydrate sulfotransferase 15 Gene

中文名称：碳水化合物磺基转移酶 15

种属: Homo sapiens

同用名: BRAG; GALNAC4S-6ST

关于 CHST15

功能概要

硫酸软骨素 (CS) 是一种糖胺聚糖，它是细胞外基质的重要结构成分，可与蛋白质连接形成蛋白聚糖。硫酸软骨素 E (CS-E) 是硫酸软骨素的异构体，其中 C-4 和 C-6 羟基被硫酸化。该基因编码一种 II 型跨膜糖蛋白，它作为磺基转移酶将硫酸盐转移到硫酸软骨素的 C-6 羟醛基团。该基因还被鉴定为与 B 细胞中的 RAG1 共表达，并可能充当 B 细胞表面信号受体。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 7 月]

Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]