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  2. TDP2 - tyrosyl-DNA phosphodiesterase 2 Gene

TDP2 - tyrosyl-DNA phosphodiesterase 2 Gene

中文名称:酪氨酰 DNA 磷酸二酯酶 2

种属: Homo sapiens

同用名: EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3

基因 ID: 51567 | 基因类型: protein coding

关于 TDP2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,649,979-24,666,899 (from NCBI)

This gene has 5 transcripts (splice variants), 272 orthologues and is associated with 2 phenotypes. Broad expression in small intestine (RPKM 97.5), colon (RPKM 87.6) and 24 other tissues.

功能概要

该基因编码二价阳离子依赖性磷酸二酯酶超家族的成员。编码的蛋白质与 CD40、肿瘤坏死因子 (TNF) 受体 75 和 TNF 受体相关因子 (TRAF) 相关,并抑制核因子-kappa-B 激活。这种蛋白质与 APE1 核酸内切酶具有序列和结构相似性,后者参与 DNA 修复和转录因子的激活。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF Receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 Endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

TDP2 基因产物(1)

mRNA Protein Name
NM_016614.3 NP_057698.2 tyrosyl-DNA phosphodiesterase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 5'-tyrosyl-DNA phosphodiesterase activity IDA
IDA: 通过直接分析推断
19794497 GOA
enables 5'-tyrosyl-DNA phosphodiesterase activity IMP
IMP: 通过突变表型推断
21030584 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
22405347 GOA
enables manganese ion binding IDA
IDA: 通过直接分析推断
22822062 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18039968 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
22822062 GOA
enables tyrosyl-RNA phosphodiesterase activity IDA
IDA: 通过直接分析推断
22908287 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair IDA
IDA: 通过直接分析推断
19794497 GOA
involved in double-strand break repair IMP
IMP: 通过突变表型推断
21030584 GOA
involved in neuron development IMP
IMP: 通过突变表型推断
24658003 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
19794497 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22908287 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22908287 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TDP2 蛋白结构

UBA_4

UBA_4: UBA-like domain (31 - 63)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (117 - 351)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

tyrosyl-DNA phosphodiesterase 2

5'-Tyr-DNA phosphodiesterase

TDP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TDP2 O95551 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
TDP2 O95551 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
TDP2 O95551 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属内
TDP2 O95551 BLK Homo sapiens P51451
Validated Y2H
32296183
种属内
TDP2 O95551 ATXN3 Homo sapiens P54252
Y2H Array
32814053
种属内
TDP2 O95551 ATXN3 Homo sapiens P54252
Validated Y2H
32814053
种属内
TDP2 O95551 ATXN3 Homo sapiens P54252
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, Autosomal Recessive 23

SCAR23

Autosomal Recessive Spinocerebellar Ataxia 23

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency

Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 23

Spinocerebellar Ataxia, Autosomal Recessive, 23

Ataxia, Spinocerebellar, Autosomal Recessive, Type 23

Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP

Spinocerebellar Ataxia Type 1 With Axonal Neuropathy

Scan1

Spinocerebellar Ataxia With Axonal Neuropathy Type 1

Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy

Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy

Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy

Spinocerebellar Ataxia With Axonal Neuropathy

Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy

Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Dyslexia
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TDP2 VGNC VGNC:35714
Macaca mulatta TDP2 VGNC VGNC:78403
Felis catus TDP2 VGNC VGNC:97658
Canis familiaris TDP2 VGNC VGNC:47219
Mus musculus TDP2 MGD MGI:1860486
Rattus norvegicus TDP2 RGD RGD:1560342