UFM1 - ubiquitin fold modifier 1 Gene

中文名称：泛素折叠修饰符 1

种属: Homo sapiens

同用名: HLD14; BM-002; C13orf20

基因 ID: 51569 | 基因类型: protein coding

关于 UFM1

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:38,349,851-38,363,619 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 26.2), endometrium (RPKM 24.1) and 25 other tissues.

功能概要

UFM1 是一种泛素样蛋白，通过 E1 样激活酶 UBA5 (UBE1DC1；MIM 610552) 和 E2 样结合酶 UFC1 (MIM 610554) 以类似于泛素化的方式与靶蛋白结合 (参见 UBE2M；MIM 603173) (Komatsu 等人，2004 [PubMed 15071506]) 。[OMIM 提供，2008 年 12 月]

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating Enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating Enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

UFM1 基因产物(5)

mRNA	Protein	Name
NM_001286703.2	NP_001273632.1	ubiquitin-fold modifier 1 isoform 2
NM_001286704.2	NP_001273633.1	ubiquitin-fold modifier 1 isoform 3
NM_001286705.2	NP_001273634.1	ubiquitin-fold modifier 1 isoform 4
NM_001286706.2	NP_001273635.1	ubiquitin-fold modifier 1 isoform 4
NM_016617.4	NP_057701.1	ubiquitin-fold modifier 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	20562859	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in brain development	IMP IMP: 通过突变表型推断	29868776	GOA
involved in negative regulation of protein import into nucleus	IMP IMP: 通过突变表型推断	28393202	GOA
involved in protein K69-linked ufmylation	IDA IDA: 通过直接分析推断	25219498	GOA
involved in protein ufmylation	IDA IDA: 通过直接分析推断	15071506	GOA
involved in protein ufmylation	IMP IMP: 通过突变表型推断	29868776	GOA
involved in regulation of intracellular estrogen receptor signaling pathway	IDA IDA: 通过直接分析推断	25219498	GOA
acts upstream of or within response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	23152784	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	32160526	GOA
involved in reticulophagy	IMP IMP: 通过突变表型推断	32160526	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15071506	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15071506	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UFM1 蛋白结构

Ufm1

0
85 a.a.

蛋白主名

其他名称

ubiquitin-fold modifier 1

UFM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UFM1	P61960	KCTD21	Homo sapiens	Q4G0X4	Y2H Prey Pooling	32296183
种属内	UFM1	P61960	KCTD21	Homo sapiens	Q4G0X4	Validated Y2H	32296183
种属内	UFM1	P61960	KCTD21	Homo sapiens	Q4G0X4	Y2H Array	32296183
种属内	UFM1	P61960	S100A6	Homo sapiens	P06703	Anti Tag CoIP	33961781
种属内	UFM1	P61960	S100A6	Homo sapiens	P06703	Anti Tag CoIP	28514442
种属内	UFM1	P61960	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
种属内	UFM1	P61960	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
种属内	UFM1	P61960	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

UFM1 抗体

目录号	产品名	应用	反应物种
HY-P81832	UFM1 Antibody (YA1577)	WB, IHC-P, IP	Human, Mouse

关联疾病

疾病名称

别名

Leukodystrophy, Hypomyelinating, 14

HLD14	Hypomyelinating Leukodystrophy 14
Leukodystrophy, Hypomyelinating, Type 14

Leukodystrophy, Hypomyelinating, 6

Habc	Hypomyelinating Leukodystrophy 6
HLD6	H-Abc
Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum	Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum
Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum	HLD
Leukodystrophy, Hypomyelinating, Type 6

Beukes Hip Dysplasia

Hip Dysplasia, Beukes Type	Beukes Familial Hip Dysplasia
BFHD	Cilliers-Beighton Syndrome
Osteoarthropathy, Premature Degenerative, Of Hip	Premature Degenerative Osteoarthropathy Of The Hip
BHD	Beukes Type Hip Dysplasia
Hip Dysplasia Beukes Type	Premature Degenerative Osteoarthropathy
Dysplasia, Hip, Beukes Type

Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24	Autosomal Recessive Spinocerebellar Ataxia 24
Spinocerebellar Ataxia, Autosomal Recessive, 24	Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Renal Cysts And Diabetes Syndrome

RCAD	Mody5
Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes	Cakut With Diabetes
Maturity-Onset Diabetes Of The Young Type 5	Tubulointerstitial Kidney Disease, Autosomal Dominant, 3
Adtkd3	Atypical Familial Juvenile Hyperuricemic Nephropathy
Atypical Fjhn	Familial Hypoplastic Glomerulocystic Kidney
Maturity-Onset Diabetes Of The Young, Type 5	Hyperuricemic Nephropathy, Familial Juvenile, Atypical
Fjhn, Atypical	Glomerulocystic Kidney Disease, Hypoplastic Type
Glomerulocystic Kidney, Familial Hypoplastic	Hypoplastic Type Glomerulocystic Kidney Disease
Glomerulocystic Kidney Disease Hypoplastic Type	Renal-Diabetes Mody5 Syndrome

Developmental And Epileptic Encephalopathy 44

DEE44	Epileptic Encephalopathy, Early Infantile, 44
Eiee44	Developmental And Epileptic Encephalopathy, 44
Early Infantile Epileptic Encephalopathy 44	Encephalopathy, Epileptic, Early Infantile, Type 44

Leukodystrophy

Leukodystrophies

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15416	UFM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	UFM1	VGNC	VGNC:54385
Mus musculus	UFM1	MGD	MGI:1915140
Felis catus	UFM1	VGNC	VGNC:102359
Rattus norvegicus	UFM1	RGD	RGD:1304890
Bos taurus	UFM1	VGNC	VGNC:107013
Macaca mulatta	UFM1	VGNC	VGNC:106310
Others	UFM1	NCBI

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站点地图隐私声明

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UFM1 - ubiquitin fold modifier 1 Gene

关于 UFM1

功能概要

UFM1 基因产物(5)

UFM1 蛋白结构

UFM1 蛋白互作信息

UFM1 抗体

关联疾病

直系同源

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UFM1 - ubiquitin fold modifier 1 Gene

关于 UFM1

功能概要

UFM1 基因产物(5)

UFM1 蛋白结构

UFM1 蛋白互作信息

UFM1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z