2. Gene
  3. CYRIB - CYFIP related Rac1 interactor B Gene

CYRIB - CYFIP related Rac1 interactor B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CYFIP 相关的 Rac1 相互作用子 B

种属: Homo sapiens

同用名: L1; CYRI; BM-009; CYRI-B; FAM49B

基因 ID: 51571 | 基因类型: protein coding

关于 CYRIB

Cytogenetic location: 8q24.21 Genomic coordinates (GRCh38): 8:129,839,593-130,017,129 (from NCBI)

This gene has 31 transcripts (splice variants), 274 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 26.7), appendix (RPKM 26.4) and 24 other tissues.

功能概要

启用小 GTPase 绑定活动。涉及多个过程，包括细胞对细菌来源分子的反应；小 GTPase 介导的信号转导的负调节；和细胞器组织的调节。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables small GTPase binding activity. Involved in several processes, including cellular response to molecule of Bacterial origin; negative regulation of small GTPase mediated signal transduction; and regulation of organelle organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

CYRIB 基因产物(78)

mRNA Protein Name
NM_001256763.2 NP_001243692.1 CYFIP-related Rac1 interactor B isoform 1
NM_001330612.2 NP_001317541.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353242.2 NP_001340171.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353243.2 NP_001340172.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353244.2 NP_001340173.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353245.1 NP_001340174.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353246.1 NP_001340175.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353247.1 NP_001340176.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353248.2 NP_001340177.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353249.1 NP_001340178.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353250.1 NP_001340179.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353251.1 NP_001340180.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353252.1 NP_001340181.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353253.1 NP_001340182.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353254.2 NP_001340183.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353255.1 NP_001340184.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353256.2 NP_001340185.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353257.2 NP_001340186.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353258.2 NP_001340187.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353259.2 NP_001340188.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353260.2 NP_001340189.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353261.2 NP_001340190.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353262.2 NP_001340191.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353263.2 NP_001340192.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353264.2 NP_001340193.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353265.2 NP_001340194.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353266.2 NP_001340195.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353267.2 NP_001340196.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353268.2 NP_001340197.1 CYFIP-related Rac1 interactor B isoform 1
NM_001353269.1 NP_001340198.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353270.1 NP_001340199.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353271.1 NP_001340200.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353272.1 NP_001340201.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353273.1 NP_001340202.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353274.1 NP_001340203.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353275.1 NP_001340204.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353276.2 NP_001340205.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353277.1 NP_001340206.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353278.1 NP_001340207.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353279.1 NP_001340208.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353280.1 NP_001340209.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353281.1 NP_001340210.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353282.2 NP_001340211.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353283.2 NP_001340212.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353284.2 NP_001340213.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353285.2 NP_001340214.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353286.2 NP_001340215.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353287.2 NP_001340216.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353288.2 NP_001340217.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353289.2 NP_001340218.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353290.2 NP_001340219.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353291.2 NP_001340220.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353292.2 NP_001340221.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353293.2 NP_001340222.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353294.2 NP_001340223.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353295.2 NP_001340224.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353296.2 NP_001340225.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353297.2 NP_001340226.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353298.2 NP_001340227.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353299.2 NP_001340228.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353300.2 NP_001340229.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353301.2 NP_001340230.1 CYFIP-related Rac1 interactor B isoform 2
NM_001353302.1 NP_001340231.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353303.1 NP_001340232.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353304.1 NP_001340233.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353305.1 NP_001340234.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353306.2 NP_001340235.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353307.2 NP_001340236.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353308.1 NP_001340237.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353309.1 NP_001340238.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353310.2 NP_001340239.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353311.2 NP_001340240.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353312.2 NP_001340241.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353313.2 NP_001340242.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353314.2 NP_001340243.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353315.2 NP_001340244.1 CYFIP-related Rac1 interactor B isoform 3
NM_001353316.2 NP_001340245.1 CYFIP-related Rac1 interactor B isoform 4
NM_016623.5 NP_057707.3 CYFIP-related Rac1 interactor B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
30250061 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to molecule of bacterial origin IMP
IMP: 通过突变表型推断
31285585 GOA
involved in negative regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
30250061 GOA
involved in negative regulation of small GTPase mediated signal transduction IMP
IMP: 通过突变表型推断
30250061 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
30250061 GOA
involved in regulation of chemotaxis IMP
IMP: 通过突变表型推断
30250061 GOA
involved in regulation of establishment of cell polarity IMP
IMP: 通过突变表型推断
30250061 GOA
involved in regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
29059164 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
29059164 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYRIB 蛋白结构

DUF1394

DUF1394: Protein of unknown function (DUF1394) (17 - 320)

  • 0
  • 100
  • 200
  • 300
  • 324 a.a.
蛋白主名 其他名称

CYFIP-related Rac1 interactor B

FAM49B/JPH1 fusion

CYRIB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
种属内
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
种属内
CYRIB Q9NUQ9 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
种属内
CYRIB Q9NUQ9 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
种属内
CYRIB Q9NUQ9 HIP1 Homo sapiens O00291
Y2H Array
32296183
种属内
CYRIB Q9NUQ9 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cardiomyopathy, Dilated, 3b

Dilated Cardiomyopathy 3b

CMD3B

X-Linked Dilated Cardiomyopathy

Xlcm

Dmd-Associated Dilated Cardiomyopathy

Cardiomyopathy, Dilated, X-Linked

Dmd-Related Dilated Cardiomyopathy

Xldc

Cardiomyopathy, Dilated, X-Linked 3b

Cardiomyopathy, Dilated, Type 3b
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03492 CYRIB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CYRIB RGD RGD:1307697
Mus musculus CYRIB MGD MGI:1923520
Felis catus CYRIB VGNC VGNC:62115
Canis familiaris CYRIB VGNC VGNC:40686
Macaca mulatta CYRIB VGNC VGNC:72345
Bos taurus CYRIB VGNC VGNC:28819
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