DPH5 - diphthamide biosynthesis 5 Gene

中文名称：双苯二甲胺生物合成 5

种属: Homo sapiens

同用名: AD-018; CGI-30; NEDSFF; NPD015; HSPC143

关于 DPH5

功能概要

该基因编码双苯二胺合成途径的一个组成部分。 Diphthamide 是一种翻译后修饰的组氨酸残基，仅在翻译延伸因子 2 上发现。从古细菌到人类，它都是保守的，并且是白喉毒素和假单胞菌外毒素 A 的目标，可阻止细胞蛋白质合成。该蛋白质的酵母和中国仓鼠同系物催化组氨酸残基在延伸因子 2 上的三甲基化，产生二萘部分，随后酰胺化产生二苯甲酰胺。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]