PADI3 - peptidyl arginine deiminase 3 Gene

中文名称：肽基精氨酸脱亚胺酶 3

种属: Homo sapiens

同用名: PAD3; PDI3; UHS1

关于 PADI3

功能概要

该基因编码肽基精氨酸脱亚胺酶家族的成员，该酶通过在钙离子存在下将精氨酸残基转化为瓜氨酸来催化蛋白质的翻译后脱亚胺。该家族成员具有不同的底物特异性和组织特异性表达模式。 III 型酶在毛囊形成过程中调节毛发结构蛋白，例如毛囊中的聚丝蛋白和内根鞘中的毛透明蛋白。与 I 型酶一起，这种酶也可能在表皮的终末分化中发挥作用。该基因与其他四个旁系同源基因存在于一个簇中。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the peptidyl arginine deiminase family of Enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III Enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I Enzyme, this Enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four Other paralogous genes. [provided by RefSeq, Jul 2008]