ARID4B - AT-rich interaction domain 4B Gene

中文名称：AT 富交互域 4B

种属: Homo sapiens

同用名: BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1

基因 ID: 51742 | 基因类型: protein coding

关于 ARID4B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,166,902-235,328,179 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 11.3) and 25 other tissues.

功能概要

该基因编码的蛋白质与视网膜母细胞瘤结合蛋白-1 具有序列相似性。编码的蛋白质是组蛋白脱乙酰酶依赖性 SIN3A 转录辅阻遏物复合物的一个亚基，它在多种细胞过程中发挥作用，包括增殖、分化、细胞凋亡、肿瘤发生和细胞命运决定。该基因产物被从乳腺癌患者身上分离出来的 IgG 抗体识别，似乎是与广泛的人类恶性肿瘤相关的分子标记。编码不同亚型的替代转录剪接变体已经被表征。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, Apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast Cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

ARID4B 基因产物(3)

mRNA	Protein	Name
NM_001206794.2	NP_001193723.1	AT-rich interactive domain-containing protein 4B isoform 1
NM_016374.6	NP_057458.4	AT-rich interactive domain-containing protein 4B isoform 1
NM_031371.4	NP_112739.2	AT-rich interactive domain-containing protein 4B isoform 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	EXP EXP: 通过实验结果推断	33675746	GOA
enables DNA binding	IMP IMP: 通过突变表型推断	33675746	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20195357	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARID4B 蛋白结构

RBB1NT

ARID

Tudor-knot

0
300
600
900
1200
1312 a.a.

蛋白主名

其他名称

AT-rich interactive domain-containing protein 4B

180 kDa Sin3-associated polypeptide

ARID4B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ARID4B	Q4LE39	ETS1	Homo sapiens	P14921	TAP	20195357

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00972	ARID4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ARID4B	VGNC	VGNC:38099
Bos taurus	ARID4B	VGNC	VGNC:26130
Rattus norvegicus	ARID4B	RGD	RGD:619919
Mus musculus	ARID4B	MGD	MGI:2137512
Felis catus	ARID4B	VGNC	VGNC:59917
Macaca mulatta	ARID4B	VGNC	VGNC:69831

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARID4B - AT-rich interaction domain 4B Gene

关于 ARID4B

功能概要

ARID4B 基因产物(3)

ARID4B 蛋白结构

ARID4B 蛋白互作信息

关联疾病

直系同源

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ARID4B - AT-rich interaction domain 4B Gene

关于 ARID4B

功能概要

ARID4B 基因产物(3)

ARID4B 蛋白结构

ARID4B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z