RSF1 - remodeling and spacing factor 1 Gene

中文名称：重构和间距因子 1

种属: Homo sapiens

同用名: XAP8; p325; HBXAP; RSF-1

基因 ID: 51773 | 基因类型: protein coding

关于 RSF1

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,660,009-77,872,232 (from NCBI)

This gene has 12 transcripts (splice variants), 258 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 7.3), thyroid (RPKM 7.0) and 25 other tissues.

功能概要

该基因编码一种与乙型肝炎病毒 X 蛋白 (HBX) 相互作用的核蛋白，并通过 HBX 转录激活因子促进乙型肝炎病毒基因的转录，表明这种相互作用在病毒生命周期中发挥作用。该蛋白还与 SNF2H 蛋白相互作用形成 RSF 染色质重塑复合物，其中 SNF2H 亚基充当核小体依赖性 ATP 酶，而该蛋白充当组蛋白伴侣。[RefSeq 提供，2011 年 9 月]

This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

RSF1 基因产物(1)

mRNA	Protein	Name
NM_016578.4	NP_057662.3	remodeling and spacing factor 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables ATP hydrolysis activity	IDA IDA: 通过直接分析推断	12972596	GOA
enables histone binding	IDA IDA: 通过直接分析推断	12972596	GOA
enables histone octamer slider activity	IDA IDA: 通过直接分析推断	9836642	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12972596	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA-templated transcription initiation	IDA IDA: 通过直接分析推断	9836642	GOA
involved in chromatin organization	IDA IDA: 通过直接分析推断	11691835	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	9836642	GOA
involved in negative regulation of DNA binding	IDA IDA: 通过直接分析推断	12972596	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11944984	GOA
involved in nucleosome assembly	EXP EXP: 通过实验结果推断	11691835	GOA
involved in nucleosome assembly	IDA IDA: 通过直接分析推断	12972596	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11788598	GOA
involved in positive regulation of viral transcription	IDA IDA: 通过直接分析推断	11788598	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12972596	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RSF complex	IPI IPI: 通过物理相互作用推断	9836642	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11788598	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RSF1 蛋白结构

WHIM1

WSD

PHD

0
300
600
900
1200
1441 a.a.

蛋白主名

其他名称

remodeling and spacing factor 1

HBV pX-associated protein 8

RSF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RSF1	Q96T23	SMARCA5	Homo sapiens	O60264	Anti Bait CoIP	12972596
种属内	RSF1	Q96T23	SMARCA5	Homo sapiens	O60264	Anti Tag CoIP	12972596

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Ovarian Melanoma

Retinitis Pigmentosa 31

RP31	Retinitis Pigmentosa-31
Retinitis Pigmentosa, Type 31

Retinitis Pigmentosa 12

RP12	Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium
Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium	Rp With Or Without Pprpe
Retinitis Pigmentosa-12

Ovarian Serous Carcinoma

Ovarian Serous Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12298	RSF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RSF1	RGD	RGD:1311245
Felis catus	RSF1	VGNC	VGNC:64788
Mus musculus	RSF1	MGD	MGI:2682305
Macaca mulatta	RSF1	VGNC	VGNC:77044
Canis familiaris	RSF1	VGNC	VGNC:45773
Bos taurus	RSF1	VGNC	VGNC:34178
Macaca fascicularis	RSF1	NCBI	NCBI:102147183
Leporidae	RSF1	NCBI
Others	RSF1	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RSF1 - remodeling and spacing factor 1 Gene

关于 RSF1

功能概要

RSF1 基因产物(1)

RSF1 蛋白结构

RSF1 蛋白互作信息

关联疾病

直系同源

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RSF1 - remodeling and spacing factor 1 Gene

关于 RSF1

功能概要

RSF1 基因产物(1)

RSF1 蛋白结构

RSF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z