2. Gene
  3. PFKP - phosphofructokinase, platelet Gene

PFKP - phosphofructokinase, platelet Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸果糖激酶，血小板

种属: Homo sapiens

同用名: PFKF; PFK-C; PFK-P; ATP-PFK

基因 ID: 5214 | 基因类型: protein coding

关于 PFKP

Cytogenetic location: 10p15.2 Genomic coordinates (GRCh38): 10:3,067,548-3,136,805 (from NCBI)

This gene has 17 transcripts (splice variants), 296 orthologues and 2 paralogues. Broad expression in testis (RPKM 49.8), brain (RPKM 37.5) and 23 other tissues.

功能概要

该基因编码磷酸果糖激酶 A 蛋白家族的成员。编码的酶是磷酸果糖激酶的血小板特异性亚型，在糖酵解调节中起着关键作用。该基因可能在某些癌症的代谢重编程中发挥作用，包括透明细胞肾细胞癌以及膀胱癌、乳腺癌和肺癌。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the phosphofructokinase A protein family. The encoded Enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and Cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

PFKP 基因产物(12)

mRNA Protein Name
NM_001242339.2 NP_001229268.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 2
NM_001323067.2 NP_001309996.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 3
NM_001323068.2 NP_001309997.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 4
NM_001323069.2 NP_001309998.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 5
NM_001323070.1 NP_001309999.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 6 precursor
NM_001323071.2 NP_001310000.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001323072.2 NP_001310001.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001323073.1 NP_001310002.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 8 precursor
NM_001323074.1 NP_001310003.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 8 precursor
NM_001345944.1 NP_001332873.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 7
NM_001410880.1 NP_001397809.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 9
NM_002627.5 NP_002618.1 ATP-dependent 6-phosphofructokinase, platelet type isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25985179 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
23209302 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25468996 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PFKP 蛋白结构

PFK

PFK: Phosphofructokinase (25 - 335)

PFK

PFK: Phosphofructokinase (413 - 697)

  • 0
  • 200
  • 400
  • 600
  • 784 a.a.
蛋白主名 其他名称

ATP-dependent 6-phosphofructokinase, platelet type

6-phosphofructokinase type C

PFKP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PFKP Q01813 PFKM Homo sapiens P08237
Anti Tag CoIP
33961781
种属内
PFKP Q01813 PFKM Homo sapiens P08237
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PFKP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75971 PFKP Protein, Human (sf9, His-GST) Q01813 (M1-V784) ≥95%

PFKP 抗体

目录号 产品名 应用 反应物种
HY-P81854 PFKP Antibody (YA1599) WB, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Glycogen Storage Disease Vii

Glycogen Storage Disease Type Vii

Muscle Phosphofructokinase Deficiency

Tarui Disease

GSD7

Pfkm Deficiency

Gsd Vii

Glycogen Storage Disease, Type Vii

Glycogen Storage Disease Type 7

Phosphofructokinase Deficiency

Glycogenosis Type Vii

Phosphofructokinase Myopathy

Glycogenosis 7

Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency

Gsd Due To Muscle Phosphofructokinase Deficiency

Gsd Type 7

Gsd Type Vii

Glycogenosis Due To Muscle Phosphofructokinase Deficiency

Glycogenosis Type 7

Glycogen Storage Disease 7

Gsd-Vii

Storage Disease, Glycogen, Type Vii
Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-169061 WQQ-345 / 否
HY-RS10367 PFKP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PFKP VGNC VGNC:32775
Mus musculus PFKP MGD MGI:1891833
Macaca mulatta PFKP VGNC VGNC:84899
Rattus norvegicus PFKP RGD RGD:61893
Canis familiaris PFKP VGNC VGNC:44448
Others PFKP NCBI
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