1. Gene
  2. CDK14 - cyclin dependent kinase 14 Gene

CDK14 - cyclin dependent kinase 14 Gene

中文名称:细胞周期蛋白依赖性激酶 14

种属: Homo sapiens

同用名: PFTK1; PFTAIRE1

基因 ID: 5218 | 基因类型: protein coding

关于 CDK14

Cytogenetic location: 7q21.13 Genomic coordinates (GRCh38): 7:90,596,321-91,210,590 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 26 paralogues. Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues.

功能概要

PFTK1 是 CDC2 (MIM 116940) 相关蛋白激酶家族的成员 (Yang 和 Chen,2001 [PubMed 11313143]) 。[OMIM 提供,2008 年 3 月]

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

CDK14 基因产物(4)

mRNA Protein Name
NM_001287136.1 NP_001274065.1 cyclin-dependent kinase 14 isoform c
NM_001287137.1 NP_001274066.1 cyclin-dependent kinase 14 isoform d
NM_001287135.2 NP_001274064.1 cyclin-dependent kinase 14 isoform a
NM_012395.3 NP_036527.1 cyclin-dependent kinase 14 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cyclin binding IPI
IPI: 通过物理相互作用推断
19524571 GOA
enables cyclin-dependent protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
19524571 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16775625 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
20059949 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
20059949 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
19524571 GOA
part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
IDA: 通过直接分析推断
19524571 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19524571 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDK14 蛋白结构

Pkinase

Pkinase: Protein kinase domain (135 - 419)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 14

PFTAIRE protein kinase 1

cell division protein kinase 14

serine/threonine-protein kinase PFTAIRE-1

CDK14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CDK14 O94921 CCNY Homo sapiens Q8ND76
Y2H
19524571
Intra CDK14 O94921 CCNY Homo sapiens Q8ND76
Anti Tag CoIP
19524571
Intra CDK14 O94921 CCNY Homo sapiens Q8ND76
IF
19524571
Intra CDK14 O94921 YWHAH Homo sapiens Q04917
Anti Tag CoIP
16775625
Intra CDK14 O94921 YWHAH Homo sapiens Q04917
Y2H
16775625
Intra CDK14 O94921 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Intra CDK14 O94921 YWHAE Homo sapiens P62258
Y2H
16775625
Intra CDK14 O94921 YWHAE Homo sapiens P62258
Anti Tag CoIP
16775625
Intra CDK14 O94921 YWHAB Homo sapiens P31946
Anti Tag CoIP
16775625
Intra CDK14 O94921 YWHAB Homo sapiens P31946
Y2H
16775625
Intra CDK14 O94921 YWHAQ Homo sapiens P27348
Y2H
16775625
Intra CDK14 O94921 CCND3 Homo sapiens P30281
Y2H
17517622
Intra CDK14 O94921 CCND3 Homo sapiens P30281
Anti Bait CoIP
17517622
Intra CDK14 O94921 CCND3 Homo sapiens P30281
Anti Tag CoIP
17517622
Intra CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Bait CoIP
17517622
Intra CDK14 O94921 CDKN1A Homo sapiens P38936
TAP
23602568
Intra CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Tag CoIP
33961781
Intra CDK14 O94921 CDKN1A Homo sapiens P38936
Anti Tag CoIP
17517622
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus CDK14 VGNC VGNC:106680
Canis familiaris CDK14 VGNC VGNC:39046
Rattus norvegicus CDK14 RGD RGD:1305544
Macaca mulatta CDK14 VGNC VGNC:71164
Mus musculus CDK14 MGD MGI:894318
Felis catus CDK14 VGNC VGNC:68810
Others CDK14 NCBI