2. Gene
  3. PGC - progastricsin Gene

PGC - progastricsin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：前胃素

种属: Homo sapiens

同用名: PEPC; PGII

基因 ID: 5225 | 基因类型: protein coding

关于 PGC

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,736,711-41,747,397 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 7385.5).

功能概要

该基因编码属于肽酶家族 A1 的天冬氨酸蛋白酶。编码的蛋白质是一种在胃中产生的消化酶，构成胃粘膜的主要成分。这种蛋白质也分泌到血清中。这种蛋白质被合成为一种无活性的酶原，包括一个高度碱性的前段。在低 pH 值下，通过由酶本身执行的前段的顺序裂解，该酶被转化为其活性成熟形式。该基因的多态性与胃癌的易感性有关。这种酶的血清水平被用作某些胃病的生物标志物，包括与幽门螺杆菌相关的胃炎。交替剪接导致多个转录本变体。在 1 号染色体上发现了该基因的假基因。[RefSeq 提供，2009 年 10 月]

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive Enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This Enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the Enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this Enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

PGC 基因产物(2)

mRNA Protein Name
NM_001166424.2 NP_001159896.1 gastricsin isoform 2 preproprotein
NM_002630.4 NP_002621.1 gastricsin isoform 1 preproprotein

PGC 蛋白结构

A1_Propeptide

A1_Propeptide: A1 Propeptide (18 - 46)

Asp

Asp: Eukaryotic aspartyl protease (72 - 387)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

gastricsin

pepsin C

重组 PGC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77131 Pepsinogen C/PGC Protein, Human (His) P20142-1/NP_002621.1 (I153-I239) ≥95%
HY-P77132 Pepsinogen C/PGC Protein, Human (HEK293, His) P20142-1/NP_002621.1 (A17-A388) ≥95%

关联疾病

疾病名称 别名
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia

HH14

Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0378 D-Mannitol 99.93% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-128895 KL1333 Modulator ≥98.0% Phase 2
HY-P3624 Cenderitide Agonist / Phase 2
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101491 SR-18292 Inhibitor 99.82% 否
HY-17538 ZLN005 Activator 99.94% 否
HY-113960 ERRα antagonist-1 Antagonist 99.71% 否
HY-N7439 Mogroside VI B Activator 98.97% 否
HY-17538S ZLN005-d4 Activator 99.52% 否
HY-P3455 Ac-SVVVRT-NH2 Modulator 98.50% 否
HY-P5763 Phoenixin-20 99.68% 否
HY-121152 Chiisanoside / 否
HY-N12011 11-Oxoisomogroside V Activator / 否
HY-P5763A Phoenixin-20 TFA / 否
HY-RS10380 PGC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125629 Primordazine B / 否
HY-130479 AdipoR agonist 1 / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PGC RGD RGD:3943
Felis catus PGC VGNC VGNC:68812
Bos taurus PGC VGNC VGNC:32785
Mus musculus PGC MGD MGI:98909
Canis familiaris PGC VGNC VGNC:57228
Macaca mulatta PGC VGNC VGNC:83442
Others PGC NCBI
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