2. Metabolic Enzyme/Protease Apoptosis GPCR/G Protein Neuronal Signaling TGF-beta/Smad Stem Cell/Wnt
  3. Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA
  4. D-Mannitol

D-Mannitol  (Synonyms: D-甘露醇; Mannitol; Mannite)

目录号: HY-N0378 纯度: 99.93%
COA 产品使用指南

摩尔计算器

D-Mannitol (Mannitol) 是一种具有口服活性的广泛应用于食品和制药业的抗阻性糖，可以通过盲肠发酵促进钙和镁的吸收和保留，同时作为渗透性利尿剂减轻组织水肿。D-Mannitol 能增强棕色脂肪形成，提升胰岛素效应，降低血糖水平，并通过启动 β3-肾上腺素能受体 (β3-AR)、PGC1α 和 PKA 的途径诱导白色脂肪细胞向棕色脂肪细胞转变。

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D-Mannitol Chemical Structure

D-Mannitol Chemical Structure

CAS No. : 69-65-8

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥500
In-stock
500 mg ￥400
In-stock
5 g ￥500
In-stock
10 g ￥800
In-stock
50 g   询价  

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Customer Review

Other Forms of D-Mannitol:

D-Mannitol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

Beta-3 adrenergic receptor

 

体外研究
(In Vitro)

D-Mannitol (10 μM) 在分化的 3T3-L1 细胞模型中可以增加线粒体的数量并促进棕色脂肪相关基因的表达[7]。
D-Mannitol (10 μM; 7 天) 在3T3-L1 脂肪细胞细胞中具有刺激棕色脂肪形成、增强胰岛素效应、降低血糖水平以及促进脂肪氧化和白色脂肪向米色脂肪的转化的作用[7]。
D-Mannitol (10 μM; 7 天) 通过激活 β3-肾上腺素能受体 ( β3-AR)， PGC1α 和 PKA 诱导白色脂肪细胞褐变[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-Mannitol 相关抗体:

Western Blot Analysis[7]

Cell Line: 3T3-L1 Adipocytes
Concentration: 10 μM
Incubation Time: 7 days
Result: Increased expression of PGC1α, a key transcriptional coactivator of UCP1, also increased expression of UCP1 and PPARγ proteins, which helped to enhance the effects of insulin and lower blood sugar levels.
Triggered the expression of the FGF21 gene, which is associated with thermogenic programming.
Activation of AMPK and phosphorylation of ACC and HMGCR promoted β-oxidation, and eliminated UCP1 and ACC expression when AMPK was blocked.

RT-PCR[7]

Cell Line: 3T3-L1 Adipocytes
Concentration: 10 μM
Incubation Time:
Result: Increased the expression of brown fat associated genes such as PPARγ coactivator 1α (PGC1α), PR domain 16 (PRDM16), and UCP1.
Increased the expression of genes related to energy expenditure and heat production.
体内研究
(In Vivo)

D-Mannitol (口服; 7 或 28 天) 在雄性 Wistar 大鼠模型中通过在盲肠中发酵，促进钙和镁的吸收和保留[5]。
D-Mannitol (0.5, 2.5, 1.5 g/kg; 静脉注射; 每隔 4 小时一次; 共 24 小时) 在缺血性皮质梗死的大鼠模型中的反复输注，会导致梗死区及同侧半球 H2O 的百分比减少以及组织压力的降低[6]。
D-Mannitol (250, 500 mg/kg; 口服; 3 周) 在小鼠模型中通过脂质 β-氧化增加能量消耗，从而有助于体内腹股沟白色脂肪组织 (iWAT) 的棕色化[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-wk-old growing male Wistar rats[4]
Dosage: 20-80 g/kg
Administration: Oral gavage (p.o.), 28 days
Result: Improved absorption and retention of calcium (Ca) and magnesium (Mg).
Animal Model: 9-wk-old growing male Wistar rats[4]
Dosage: 40 g/kg, 80 g/kg
Administration: Oral gavage (p.o.), 7 days
Result: Increased cecal weight and tissue weight, and reduced pH.
Animal Model: Adult cats[5]
Dosage: 0.33 gm/kg
Administration: Intraperitoneal injection (i.p.), 4-hour intervals, single dose or five doses
Result: After multiple injections, the osmotic concentration gradient between vasogenic cerebral edema and plasma was reversed, which was associated with the worsening of vasogenic cerebral edema.
Animal Model: Ischemic cortex infarction model in rats[6]
Dosage: 0.5, 2.5, 1.5 g/kg
Administration: Intravenous injection (i.v.), 4-hour intervals, 24h
Result: Repeated infusion results in a dose-dependent increase in plasma osmotic pressure and a dose-dependent decrease in the percentage of water in the ischemic cerebral tissue of the arterial cortex and ipsilateral hemisphere.
Significantly reduced organizational stress.
Animal Model: Mouse Model[7]
Dosage: 250 mg/kg, 500 mg/kg
Administration: Oral gavage (p.o.), 3 weeks
Result: Caused a significant decrease in the average body weight of the mice.
Increased the conversion of white adipose tissue to brown tissue.
Led to a significant increase in the expression of genes regulating mitochondrial heat production and lipid oxidation, such as Cidea, CPT1, UCP1, and PGC1α.
Clinical Trial
分子量

182.17

Formula

C6H14O6
CAS 号
性状

固体

颜色

White to off-white

中文名称

D-甘露醇；已六醇 D-甘露密醇；D-木蜜醇；甘露蜜醇；D-甘露糖醇；虫草酸；哌喃甘露糖
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 36 mg/mL (197.62 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.4894 mL 27.4469 mL 54.8938 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (548.94 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.93%

COA (283 KB) RP-HPLC (237 KB)

产品使用指南 (1538 KB)
参考文献

D-Mannitol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4894 mL 27.4469 mL 54.8938 mL 137.2345 mL
5 mM 1.0979 mL 5.4894 mL 10.9788 mL 27.4469 mL
10 mM 0.5489 mL 2.7447 mL 5.4894 mL 13.7234 mL
15 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
20 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8617 mL
25 mM 0.2196 mL 1.0979 mL 2.1958 mL 5.4894 mL
30 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
40 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4309 mL
50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.7447 mL
60 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Mannitol69-65-8Mannitol ManniteD-甘露醇已六醇 D-甘露密醇D-木蜜醇甘露蜜醇D-甘露糖醇虫草酸哌喃甘露糖Endogenous MetaboliteApoptosisAdrenergic ReceptorPGC-1αPKABeta ReceptorPPARγ coactivator-1αProtein kinase ACalciumMagnesiumIschemic cortex infarction model in ratsVasogenic edemaInhibitorinhibitorinhibit

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