D-Mannitol-¹³C₆  (Synonyms: D-甘露醇-¹³C₆; Mannitol-¹³C₆; Mannite-¹³C₆)

D-Mannitol-¹³C₆ is the ¹³C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

188.13

¹³C₆H₁₄O₆

287112-34-9

69-65-8

D-甘露醇-¹³C₆

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284(52): p. 36670-9.  [Content Brief]

  [3]. Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55(3): p. 242-51.  [Content Brief]

  [4]. Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80(2): p. 157-62.  [Content Brief]