2. Gene
  3. SERPINA4 - serpin family A member 4 Gene

SERPINA4 - serpin family A member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：serpin 家族成员 4

种属: Homo sapiens

同用名: KAL; KST; PI4; KLST; PI-4; kallistatin

基因 ID: 5267 | 基因类型: protein coding

关于 SERPINA4

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,561,442-94,569,906 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 36 paralogues. Biased expression in liver (RPKM 98.1), gall bladder (RPKM 28.7) and 2 other tissues.

功能概要

预测可启用丝氨酸型内肽酶抑制剂活性。预测参与内肽酶活性的负调节。位于细胞外外泌体。糖尿病视网膜病变的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA4 基因产物(3)

mRNA Protein Name
NM_001289032.2 NP_001275961.1 kallistatin isoform 1
NM_001289033.2 NP_001275962.1 kallistatin isoform 2 precursor
NM_006215.4 NP_006206.2 kallistatin isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINA4 蛋白结构

Serpin

Serpin: Serpin (serine protease inhibitor) (54 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
蛋白主名 其他名称

kallistatin

kallikrein inhibitor

重组 SERPINA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71143 Serpin A4 Protein, Human (HEK293, His) P29622 (Q21-P427) ≥95%

关联疾病

疾病名称 别名
Cerebral Hemisphere Lipoma

Lipoma Of The Cerebral Hemisphere
Corpus Callosum Lipoma

Lipoma Of The Corpus Callosum

Lipoma Of Corpus Callosum
Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2

Acromegaly Due To Pituitary Adenoma 2

Acromegaly, X-Linked

Growth Hormone Secreting Pituitary Adenoma 2

Pituitary Adenoma, Growth Hormone-Secreting, 2

Pituitary Adenoma 2, Gh-Secreting

Gh-Secreting Pituitary Adenoma 2

X-Linked Acromegaly

Adenoma, Pituitary, Growth Hormone-Secreting, Type 2
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12700 SERPINA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SERPINA4 VGNC VGNC:68836
Bos taurus SERPINA4 VGNC VGNC:34467
Rattus norvegicus SERPINA4 RGD RGD:708581
Canis familiaris SERPINA4 VGNC VGNC:46025
Others SERPINA4 NCBI
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