2. Gene
  3. PIGF - phosphatidylinositol glycan anchor biosynthesis class F Gene

PIGF - phosphatidylinositol glycan anchor biosynthesis class F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇聚糖锚生物合成类 F

种属: Homo sapiens

同用名: OORS

基因 ID: 5281 | 基因类型: protein coding

关于 PIGF

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,580,937-46,617,041 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 42.1), heart (RPKM 35.0) and 25 other tissues.

功能概要

该基因编码一种参与糖基磷脂酰肌醇 (GPI) -锚生物合成的蛋白质。 GPI 锚是一种在其核心主链中含有三个甘露糖分子的糖脂，存在于许多血细胞中，用于将蛋白质锚定到细胞表面。编码的蛋白质和另一种 GPI 合成蛋白质 PIGO 在将乙醇胺磷酸盐转移到 GPI 中的第三个甘露糖中发挥作用。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PIGF 基因产物(2)

mRNA Protein Name
NM_002643.4 NP_002634.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 1
NM_173074.3 NP_775097.1 phosphatidylinositol-glycan biosynthesis class F protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in GPI anchor biosynthetic process IMP
IMP: 通过突变表型推断
33386993 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIGF 蛋白结构

PIG-F

PIG-F: GPI biosynthesis protein family Pig-F (13 - 206)

  • 0
  • 100
  • 200
  • 219 a.a.
蛋白主名 其他名称

phosphatidylinositol-glycan biosynthesis class F protein

GPI11 homolog

PIGF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra PIGF Q07326 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra PIGF Q07326 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra PIGF Q07326 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra PIGF Q07326 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Prey Pooling
32296183
Intra PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Y2H Array
32296183
Intra PIGF Q07326 TMEM130 Homo sapiens Q8N3G9
Validated Y2H
32296183
Intra PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra PIGF Q07326 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra PIGF Q07326 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra PIGF Q07326 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra PIGF Q07326 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra PIGF Q07326 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome

OORS

Oors Syndrome

Glycosylphosphatidylinositol Biosynthesis Defect 24

Gpibd24
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10490 PIGF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PIGF MGD MGI:99462
Canis familiaris PIGF VGNC VGNC:44532
Bos taurus PIGF VGNC VGNC:32868
Felis catus PIGF VGNC VGNC:81148
Rattus norvegicus PIGF RGD RGD:1584658
Macaca mulatta PIGF VGNC VGNC:81499
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