2. Gene
  3. IL17D - interleukin 17D Gene

IL17D - interleukin 17D Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 17D

种属: Homo sapiens

同用名: IL-17D

基因 ID: 53342 | 基因类型: protein coding

关于 IL17D

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:20,701,513-20,723,098 (from NCBI)

This gene has 4 transcripts (splice variants), 163 orthologues and 5 paralogues. Biased expression in brain (RPKM 13.7), ovary (RPKM 2.3) and 11 other tissues.

功能概要

该基因编码的蛋白质是一种细胞因子，与 IL17 具有序列相似性。用这种细胞因子处理内皮细胞已显示可刺激其他细胞因子的产生，包括 IL6、IL8 和 CSF2/GM-CSF。发现由该细胞因子诱导的 IL8 表达增加是 NF-kappa B 依赖性的。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of Other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

IL17D 基因产物(7)

mRNA Protein Name
NM_001385221.1 NP_001372150.1 interleukin-17D isoform a precursor
NM_001385222.1 NP_001372151.1 interleukin-17D isoform b precursor
NM_001385223.1 NP_001372152.1 interleukin-17D isoform c precursor
NM_001385224.1 NP_001372153.1 interleukin-17D isoform c precursor
NM_001385225.1 NP_001372154.1 interleukin-17D isoform d
NM_001386973.1 NP_001373902.1 interleukin-17D isoform e
NM_138284.2 NP_612141.1 interleukin-17D isoform c precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
12097364 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
12097364 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
12097364 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IDA
IDA: 通过直接分析推断
12097364 GOA
involved in negative regulation of hemopoiesis IDA
IDA: 通过直接分析推断
12097364 GOA
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
12097364 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: 通过直接分析推断
12097364 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
12097364 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
12097364 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12097364 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL17D 蛋白结构

IL17

IL17: Interleukin-17 (89 - 171)

  • 0
  • 100
  • 202 a.a.
蛋白主名 其他名称

interleukin-17D

重组 IL17D 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70587 IL-17D Protein, Human Q8TAD2 (A18-P202) ≥95%
HY-P700106AF Animal-Free IL-17D Protein, Human (His) Q8TAD2 (A18-P202) ≥95%

关联疾病

疾病名称 别名
Hidradenitis Suppurativa

Acne Inversa

Suppurative Hidradenitis

Acne Inversa, Familial

Apocrinitis

Hidradenitides, Suppurative

Hidradenitis, Suppurative

Suppurative Hidradenitides

Inverse Acne
Psoriasis
Hidradenitis

Hydradenitis
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06700 IL17D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL17D RGD RGD:1595926
Mus musculus IL17D MGD MGI:2446510
Bos taurus IL17D VGNC VGNC:30120
Others IL17D NCBI
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