PRKAG3 - protein kinase AMP-activated non-catalytic subunit gamma 3 Gene

中文名称：蛋白激酶 AMP 激活的非催化亚基 γ 3

种属: Homo sapiens

同用名: AMPKG3; SMGMQTL

关于 PRKAG3

功能概要

该基因编码的蛋白质是 AMP 活化蛋白激酶 (AMPK) 的调节亚基。 AMPK 是一种异源三聚体，由一个 α 催化亚基以及非催化 β 和 γ 亚基组成。 AMPK 是一种重要的能量感应酶，可监测细胞能量状态。响应细胞代谢应激，AMPK 被激活，从而使乙酰辅酶 A 羧化酶 (ACC) 和 β-羟基β-甲基戊二酰辅酶 A 还原酶 (HMGCR) 磷酸化和失活，这些酶是参与调节脂肪酸和胆固醇从头生物合成的关键酶.该亚基是 AMPK 的伽马调节亚基之一。它主要在骨骼肌中表达。对猪对应物的研究表明，该亚基可能在骨骼肌能量代谢的调节中发挥关键作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]