1. Gene
  2. Avpr1a - arginine vasopressin receptor 1A Gene

Avpr1a - arginine vasopressin receptor 1A Gene

中文名称:精氨酸加压素受体 1A

种属: Mus musculus

同用名: V1a; AVPR; V1aR; Avpr1

基因 ID: 54140 | 基因类型: protein coding

关于 Avpr1a

Chromosome 10: 122,284,404-122,289,357 forward strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 264 orthologues, 16 paralogues and is associated with 20 phenotypes. Biased expression in liver adult (RPKM 15.9), bladder adult (RPKM 11.1) and 13 other tissues.

功能概要

该基因编码精氨酸加压素的受体,精氨酸加压素是一种神经垂体激素,参与利尿抑制、平滑肌收缩、肝糖原分解刺激和垂体促肾上腺皮质激素释放的调节。该受体代表三种 G 蛋白偶联的精氨酸加压素受体之一,其通过血管和肝组织中的磷脂酰肌醇-钙第二信使系统发挥作用 [RefSeq 提供,2008 年 7 月]

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]

Avpr1a 基因产物(1)

mRNA Protein Name
NM_016847.2 NP_058543.2 vasopressin V1a receptor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of blood pressure IMP
IMP: 通过突变表型推断
26531127 MGI
acts upstream of or within regulation of systemic arterial blood pressure by vasopressin IGI
IGI: 通过遗传相互作用推断
12486173 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Avpr1a 蛋白结构

7tmA_V1aR

7tmA_V1aR: cd15385 (51 - 363)

7tmA_V1aR

7tmA_V1aR: cd15385 (52 - 78)

7tmA_V1aR

7tmA_V1aR: cd15385 (85 - 112)

7tmA_V1aR

7tmA_V1aR: cd15385 (123 - 153)

7tmA_V1aR

7tmA_V1aR: cd15385 (165 - 186)

7tmA_V1aR

7tmA_V1aR: cd15385 (214 - 243)

7tmA_V1aR

7tmA_V1aR: cd15385 (288 - 318)

7tmA_V1aR

7tmA_V1aR: cd15385 (331 - 356)

DUF1856

DUF1856: pfam08983 (376 - 422)

  • 0
  • 100
  • 200
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  • 400
  • 423 a.a.
蛋白主名 其他名称

vasopressin V1a receptor

AVPR V1a

V1a arginine vasopressin receptor

antidiuretic hormone receptor 1a

vascular/hepatic-type arginine vasopressin receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Avpr1a NCBI NCBI:552