2. Gene
  3. Car2 - carbonic anhydrase 2 Gene

Car2 - carbonic anhydrase 2 Gene

  • 基因
  • 蛋白
  • 相关产品

中文名称：碳酸酐酶 2

种属: Rattus norvegicus

同用名: Ca2

基因 ID: 54231 | 基因类型: protein coding

关于 Car2

Primary_assembly 2: 86,741,626-86,756,818 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 285 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 2474.6), Kidney (RPKM 1633.5) and 3 other tissues.

功能概要

该基因编码的蛋白可启动碳酸盐脱水酶活性。参与几个过程，包括骨吸收的正调节；细胞 pH 值降低的正向调节；和破骨细胞分化的正调节。位于多个细胞成分中，包括细胞的顶端部分；基底外侧质膜；和微绒毛。该基因的人类直系同源物与常染色体隐性骨硬化症 3 和骨硬化症有关。与人类 CA2（碳酸酐酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables carbonate dehydratase activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of cellular pH reduction; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (Carbonic Anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Car2 基因产物(1)

mRNA Protein Name
NM_019291.1 NP_062164.1 carbonic anhydrase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbonate dehydratase activity IDA
IDA: 通过直接分析推断
6425289 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10350214 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fluid shear stress IEP
IEP: 通过表达模式推断
16777439 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
23869188 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
9655354 RGD
involved in odontogenesis of dentin-containing tooth IEP
IEP: 通过表达模式推断
8766158 RGD
involved in positive regulation of bone resorption IMP
IMP: 通过突变表型推断
8674544 RGD
involved in positive regulation of cellular pH reduction IMP
IMP: 通过突变表型推断
9665810 RGD
involved in positive regulation of osteoclast differentiation IMP
IMP: 通过突变表型推断
10523502 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
16188437 RGD
involved in response to formaldehyde IEP
IEP: 通过表达模式推断
17285311 RGD
involved in response to pH IEP
IEP: 通过表达模式推断
8141264 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
1903702 RGD
involved in response to zinc ion IEP
IEP: 通过表达模式推断
16140947 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
2129509 RGD
located in axon IDA
IDA: 通过直接分析推断
3110266 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16575514 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
102414 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
14644548 RGD
located in microvillus IDA
IDA: 通过直接分析推断
16575514 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Car2 蛋白结构

alpha_CA

alpha_CA: cl00012 (0 - 258)

  • 0
  • 100
  • 200
  • 260 a.a.
蛋白主名 其他名称

carbonic anhydrase 2

CA-II

carbonate dehydratase II

carbonic anhydrase II

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01909 Car2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01910 Car2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01934 CARS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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