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  2. GPR85 - G protein-coupled receptor 85 Gene

GPR85 - G protein-coupled receptor 85 Gene

中文名称:G 蛋白偶联受体 85

种属: Homo sapiens

同用名: SREB; SREB2

基因 ID: 54329 | 基因类型: protein coding

关于 GPR85

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:113,082,285-113,087,724 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 2 paralogues. Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues.

功能概要

蛋白偶联受体 (GPCR) 家族的成员,例如 GPR85,具有以 7 个跨膜结构域为特征的相似结构。细胞外刺激物 (例如神经递质、激素或光) 激活 GPCR,诱导由异三聚体 GTP 结合蛋白或 G 蛋白介导的细胞内信号级联反应 (Matsumoto 等人,2000 [PubMed 10833454]) 。[OMIM 提供, 2008 年 8 月]

Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, Hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GPR85 基因产物(4)

mRNA Protein Name
NM_001146265.2 NP_001139737.1 probable G-protein coupled receptor 85
NM_001146266.2 NP_001139738.1 probable G-protein coupled receptor 85
NM_001146267.2 NP_001139739.1 probable G-protein coupled receptor 85
NM_018970.7 NP_061843.3 probable G-protein coupled receptor 85
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25780553 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
25780553 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR85 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (37 - 338)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 85

seven transmembrane helix receptor

直系同源

种属 基因名 来源 基因 ID
Felis catus GPR85 VGNC VGNC:67445
Canis familiaris GPR85 VGNC VGNC:41447
Bos taurus GPR85 VGNC VGNC:29602
Mus musculus GPR85 MGD MGI:1927851
Macaca mulatta GPR85 VGNC VGNC:73147
Rattus norvegicus GPR85 RGD RGD:71011