2. Gene
  3. Dll4 - delta like canonical Notch ligand 4 Gene

Dll4 - delta like canonical Notch ligand 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Delta4

基因 ID: 54485 | 基因类型: protein coding

关于 Dll4

功能概要

Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]

Dll4 基因产物(1)

mRNA Protein Name
NM_019454.3 NP_062327.2 delta-like protein 4 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IDA
IDA: 通过直接分析推断
10837024 MGI
enables Notch binding IPI
IPI: 通过物理相互作用推断
20947685 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16000382 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
24667410 MGI
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
15466159 MGI
involved in T cell differentiation IDA
IDA: 通过直接分析推断
15146182 MGI
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
15466160 MGI
involved in blood vessel lumenization IMP
IMP: 通过突变表型推断
15466160 MGI
involved in blood vessel remodeling IMP
IMP: 通过突变表型推断
15466160 MGI
involved in branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
involved in cardiac atrium morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
involved in cardiac ventricle morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
involved in dorsal aorta morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
involved in negative regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
26114479 MGI
acts upstream of or within negative regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
18559979 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15466159 MGI
involved in pericardium morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
26114479 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
22323600 MGI
involved in regulation of neural retina development IMP
IMP: 通过突变表型推断
22323600 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: 通过突变表型推断
19389377 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: 通过突变表型推断
15466159 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

delta-like protein 4

delta-like 4

drosophila Delta homolog 4

重组 Dll4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75292 Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) Q9JI71 (S28-P525) ≥95%
HY-P75293 Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) Q9JI71 (S28-P525) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P99377 Navicixizumab Inhibitor / Phase 3
HY-P99261 Demcizumab Inhibitor ≥95.0% Phase 2
HY-P99852 Dilpacimab Inhibitor / Phase 2
HY-P99925 Enoticumab Inhibitor 99.64% Phase 1
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122094 Steppogenin Inhibitor 99.49% 否
HY-RS03810 DLL4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991033 Tovecimig / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dll4 NCBI NCBI:54567
Macaca mulatta Dll4 NCBI NCBI:704898
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