1. Gene
  2. APBB1IP - amyloid beta precursor protein binding family B member 1 interacting protein Gene

APBB1IP - amyloid beta precursor protein binding family B member 1 interacting protein Gene

中文名称:淀粉样蛋白前体蛋白结合家族 B 成员 1 相互作用蛋白

种属: Homo sapiens

同用名: RIAM; INAG1; PREL1; RARP1

基因 ID: 54518 | 基因类型: protein coding

关于 APBB1IP

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:26,438,341-26,567,803 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 4 paralogues. Broad expression in appendix (RPKM 24.2), spleen (RPKM 22.5) and 16 other tissues.

功能概要

预计参与信号转导。预计通过 T 细胞受体接触与抗原呈递细胞上的 MHC 分子结合的抗原和细胞粘附的正调节,在 T 细胞活化的上游或内部起作用。位于胞质溶胶和质膜中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

APBB1IP 基因产物(1)

mRNA Protein Name
NM_019043.4 NP_061916.3 amyloid beta A4 precursor protein-binding family B member 1-interacting protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22084112 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

APBB1IP 蛋白结构

RA

RA: Ras association (RalGDS/AF-6) domain (178 - 262)

PH

PH: PH domain (312 - 416)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
蛋白主名 其他名称

amyloid beta A4 precursor protein-binding family B member 1-interacting protein

APBB1-interacting protein 1

APBB1IP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra APBB1IP Q7Z5R6 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
Intra APBB1IP Q7Z5R6 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency 1

LAD1

Lad

Lymphocyte Function-Associated Antigen 1 Immunodeficiency

Leukocyte Adhesion Deficiency Type I

Leukocyte Adhesion Deficiency Type 1

Linear Iga Bullous Dermatosis

Linear Iga Dermatosis

Leukocyte-Adhesion Deficiency Syndrome

Lfa1 Immunodeficiency

Congenital Leukocyte Adherence Deficiency

Lad-I

Linear Iga Disease

Leukocyte Adhesion Deficiency Syndrome

Lad 1

Lfa 1 Immunodeficiency

Linear Immunoglobulin A Dermatosis

Leucocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Molecule Deficiency Type 1

Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3

LAD3

Leukocyte Adhesion Deficiency 1 Variant

Lad1v

Integrin Activation Deficiency Disease

Iadd

Leukocyte Adhesion Deficiency Type Iii

Lad1 Variant

Lad-1 Variant

Lad-Iii

Leukocyte Adhesion Deficiency-1 Variant

Leukocyte Adhesion Deficiency Type 1

Rocky Mountain Spotted Fever

Brazillian Spotted

Choix

Exanthematic Typhus Of Sao Paulo

Fiebre Maculosa

Fiebre Manchada

Sao Paulo Typhus

So Paulo Fever

Tick Typhus

Tobia Fever

Rmsf

Typhus, Tick

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta APBB1IP VGNC VGNC:100295
Canis familiaris APBB1IP VGNC VGNC:37978
Rattus norvegicus APBB1IP RGD RGD:1304795
Felis catus APBB1IP VGNC VGNC:59844
Bos taurus APBB1IP VGNC VGNC:26004
Mus musculus APBB1IP MGD MGI:1861354