2. Gene
  3. POU2F2 - POU class 2 homeobox 2 Gene

POU2F2 - POU class 2 homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：POU 2 类同源框 2

种属: Homo sapiens

同用名: OCT2; OTF2; Oct-2

基因 ID: 5452 | 基因类型: protein coding

关于 POU2F2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,086,110-42,197,936 (from NCBI)

This gene has 21 transcripts (splice variants), 261 orthologues and 17 paralogues. Broad expression in lymph node (RPKM 11.8), spleen (RPKM 7.4) and 14 other tissues.

功能概要

该基因编码的蛋白质是 POU 结构域家族的含有同源框的转录因子。编码的蛋白质结合八聚体序列 5'-ATTTGCAT-3'，这是免疫球蛋白基因启动子中常见的转录因子结合位点。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

POU2F2 基因产物(10)

mRNA Protein Name
NM_001207025.4 NP_001193954.1 POU domain, class 2, transcription factor 2 isoform 1
NM_001207026.3 NP_001193955.1 POU domain, class 2, transcription factor 2 isoform 3
NM_001247994.3 NP_001234923.1 POU domain, class 2, transcription factor 2 isoform 4
NM_001393934.1 NP_001380863.1 POU domain, class 2, transcription factor 2 isoform 5
NM_001393935.1 NP_001380864.1 POU domain, class 2, transcription factor 2 isoform 6
NM_001393936.1 NP_001380865.1 POU domain, class 2, transcription factor 2 isoform 7
NM_001394376.1 NP_001381305.1 POU domain, class 2, transcription factor 2 isoform 8
NM_001394377.1 NP_001381306.1 POU domain, class 2, transcription factor 2 isoform 9
NM_001394378.1 NP_001381307.1 POU domain, class 2, transcription factor 2 isoform 10
NM_002698.6 NP_002689.1 POU domain, class 2, transcription factor 2 isoform 2

POU2F2 蛋白结构

Pou

Pou: Pou domain - N-terminal to homeobox domain (196 - 269)

Homeobox

Homeobox: Homeobox domain (298 - 354)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

POU domain, class 2, transcription factor 2

homeobox protein

关联疾病

疾病名称 别名
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
Papilloma

Papillomatosis
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10898 POU2F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus POU2F2 VGNC VGNC:59358
Rattus norvegicus POU2F2 RGD RGD:621690
Felis catus POU2F2 VGNC VGNC:68965
Mus musculus POU2F2 MGD MGI:101897
Canis familiaris POU2F2 VGNC VGNC:44827
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