POU3F2 - POU class 3 homeobox 2 Gene

中文名称：POU 类 3 同源盒 2

种属: Homo sapiens

同用名: BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3

基因 ID: 5454 | 基因类型: protein coding

关于 POU3F2

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:98,834,574-98,839,458 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 17 paralogues.

功能概要

该基因编码 POU-III 类神经转录因子的成员。编码的蛋白质参与神经元分化并增强促肾上腺皮质激素释放激素调节基因的激活。这种蛋白质的过度表达与黑色素瘤细胞增殖的增加有关。[RefSeq 提供，2012 年 3 月]

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

POU3F2 基因产物(1)

mRNA	Protein	Name
NM_005604.4	NP_005595.2	POU domain, class 3, transcription factor 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11029584	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11029584	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	15024079	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POU3F2 蛋白结构

Pou

Homeobox

0
100
200
300
400
443 a.a.

蛋白主名

其他名称

POU domain, class 3, transcription factor 2

brain-2

POU3F2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POU3F2	P20265	EP300	Homo sapiens	Q09472	Y2H	11029584
种属内	POU3F2	P20265	POU3F2	Homo sapiens	P20265	Pull Down	11029584
种属内	POU3F2	P20265	POU3F2	Homo sapiens	P20265	Y2H	11029584
种属内	POU3F2	P20265	SOX10	Homo sapiens	P56693	Pull Down	11029584
种属内	POU3F2	P20265	EP300	Homo sapiens	Q09472	Pull Down	11029584
种属内	POU3F2	P20265	GTF2B	Homo sapiens	Q00403	Pull Down	11029584

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Microphthalmia, Syndromic 3

MCOPS3	Aeg Syndrome
Microphthalmia And Esophageal Atresia Syndrome	Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Anophthalmia-Esophageal-Genital Syndrome	Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System
Syndromic Microphthalmia 3	Sox2 Anophthalmia Syndrome
Anophthalmia Clinical With Associated Anomalies	Anophthalmia Esophageal Genital Syndrome
Anophthalmia Microphthalmia Esophageal Atresia	Syndromic Microphthalmia Type 3
Sox2-Related Eye Disorders	Anophthalmia, Clinical, With Associated Anomalies
Syndromic Microphthalmia, Type 3	Microphthalmia, Syndromic, 3
Anophthalmia/Microphthalmia-Esophageal Atresia	Microphthalmia Syndromic, Type 3

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10901	POU3F2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	POU3F2	VGNC	VGNC:106871
Rattus norvegicus	POU3F2	RGD	RGD:61946
Canis familiaris	POU3F2	VGNC	VGNC:57229
Macaca mulatta	POU3F2	VGNC	VGNC:99426
Mus musculus	POU3F2	MGD	MGI:101895

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POU3F2 - POU class 3 homeobox 2 Gene

关于 POU3F2

功能概要

POU3F2 基因产物(1)

POU3F2 蛋白结构

POU3F2 蛋白互作信息

关联疾病

直系同源

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POU3F2 - POU class 3 homeobox 2 Gene

关于 POU3F2

功能概要

POU3F2 基因产物(1)

POU3F2 蛋白结构

POU3F2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z