UGT1A10 - UDP glucuronosyltransferase family 1 member A10 Gene

中文名称：UDP 葡萄糖醛酸转移酶家族 1 成员 A10

种属: Homo sapiens

同用名: GNT1; UGT1; UDPGT; UGT1A; UGT1J; UGT-1A; UGT-1J; UGT1.1; UGT1A1; UGT1-01; UGT1-10; UGT1.10; hUG-BR1

基因 ID: 54575 | 基因类型: protein coding

关于 UGT1A10

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,636,448-233,773,300 (from NCBI)

This gene has 2 transcripts (splice variants), 1221 orthologues and 21 paralogues.

功能概要

该基因编码一种 UDP-葡萄糖醛酸转移酶，一种葡萄糖醛酸化途径的酶，可将类固醇、胆红素、激素和药物等亲脂性小分子转化为水溶性、可分泌的代谢物。该基因是编码多种 UDP-葡糖醛酸转移酶的复杂基因座的一部分。该基因座包括十三个独特的备用第一外显子，后跟四个共同外显子。四个交替的第一外显子被认为是假基因。其余九个 5' 外显子中的每一个都可以剪接至四个共同外显子，从而产生具有不同 N 末端和相同 C 末端的九种蛋白质。每个第一外显子编码底物结合位点，并由其自身的启动子调节。该基因编码的酶对霉酚酸、香豆素和喹啉具有葡萄糖醛酸酶活性。[RefSeq 提供，2008 年 7 月]

This gene encodes a UDP-glucuronosyltransferase, an Enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as Steroids, bilirubin, Hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The Enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, Coumarins, and quinolines. [provided by RefSeq, Jul 2008]

UGT1A10 基因产物(1)

mRNA	Protein	Name
NM_019075.4	NP_061948.1	UDP-glucuronosyltransferase 1A10 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	17179145	GOA
enables glucuronosyltransferase activity	IDA IDA: 通过直接分析推断	18052087	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	20610558	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	17179145	GOA
enables protein kinase C binding	IDA IDA: 通过直接分析推断	18556656	GOA
NOT enables retinoic acid binding	IDA IDA: 通过直接分析推断	20308471	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular glucuronidation	IDA IDA: 通过直接分析推断	20056724	GOA
involved in flavone metabolic process	IDA IDA: 通过直接分析推断	18052087	GOA
involved in toxin catabolic process	IDA IDA: 通过直接分析推断	18556656	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	17179145	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UGT1A10 蛋白结构

UDPGT

0
100
200
300
400
500
530 a.a.

蛋白主名

其他名称

UDP-glucuronosyltransferase 1A10

Bilirubin-specific UDPGT isozyme 1

关联疾病

疾病名称

别名

Bilirubin, Serum Level Of, Quantitative Trait Locus 1

Bilirubin, Serum Level Of, Qtl1	BILIQTL1
Bilirubin, Serum Level Of, Quantitative Trait Locus, Type 1

Hyperbilirubinemia, Transient Familial Neonatal

Lucey-Driscoll Syndrome	Transient Familial Neonatal Hyperbilirubinemia
HBLRTFN	Hyperbilirubinemia, Familial Transient Neonatal
Hyperbilirubinemia Transient Familial Neonatal	Transient Familial Hyperbilirubinemia

Crigler-Najjar Syndrome, Type Ii

Crigler-Najjar Syndrome Type 2	Hyperbilirubinemia, Crigler-Najjar Type Ii
Hblrcn2	Arias Syndrome
Crigler Najjar Syndrome Type 2	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 2
Bilirubin-Ugt Deficiency Type 2	Crigler-Najjar Syndrome 2
CN2	Cn-Ii
Crigler-Najjar Syndrome Type Ii	Crigler Najjar Syndrome, Type 2

Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome	Crigler-Najjar Syndrome Type 1
Bilirubin Udp Glucuronyl Transferase Deficiency	Crigler Najjar Syndrome
Crigler Najjar Syndrome, Type 1	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency
Bilirubin-Ugt Deficiency	Hyperbilirubinemia, Crigler-Najjar Type I
Hblrcn1	Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Hereditary Unconjugated Hyperbilirubinemia	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1
Bilirubin-Ugt Deficiency Type 1	Crigler-Najjar Syndrome 1
CN1	Cn-I
Crigler-Najjar Syndrome Type I	Hereditary Unconjugated Hyperbilirubinaemia
Ugt Deficiency	Bilirubin Glucuronosyltransferase Deficiency
Crigler-Najjar Disease Or Syndrome	Deficiency Of Glucuronosyltransferase
Glucuronyl Transferase Deficiency	Glucuronyltransferase Deficiency
Udp Glucuronyl Transferase Deficiency	Cns - [Crigler-Najjar Syndrome]
Congenital Familial Nonhemolytic Jaundice

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Acetaminophen Metabolism

Pericholangitis

Kernicterus

Bilirubin Encephalopathy	Hyperbilirubinemic Encephalopathy
Kernicterus Spectrum Disorder

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-135541	Darexaban maleate		/	否
HY-135582	Raloxifene 4'-glucuronide	Modulator	/	否
HY-135582S	Raloxifene 4'-glucuronide-d4	Modulator	/	否
HY-135582S1	Raloxifene 4'-glucuronide-d4 lithium	Modulator	/	否
HY-RS15427	UGT1A10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

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UGT1A10 - UDP glucuronosyltransferase family 1 member A10 Gene

关于 UGT1A10

功能概要

UGT1A10 基因产物(1)

UGT1A10 蛋白结构

关联疾病

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UGT1A10 - UDP glucuronosyltransferase family 1 member A10 Gene

关于 UGT1A10

功能概要

UGT1A10 基因产物(1)

UGT1A10 蛋白结构

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z