2. Gene
  3. Pde3a - phosphodiesterase 3A, cGMP inhibited Gene

Pde3a - phosphodiesterase 3A, cGMP inhibited Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 3A，cGMP 受抑制

种属: Mus musculus

同用名: A930022O17Rik

基因 ID: 54611 | 基因类型: protein coding

关于 Pde3a

Chromosome 6: 141,194,995-141,453,174 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 258 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues.

功能概要

该基因编码的蛋白可启动 3',5'-环状 AMP 磷酸二酯酶活性。作用于多个过程的上游或内部，包括卵母细胞成熟；卵母细胞发育的正向调节；和减数分裂核分裂的调节。位于胞质溶胶和膜中。以多种结构表达，包括消化系统；中枢神经系统;颅骨;泌尿生殖系统；和外皮系统。该基因的人类直系同源物与高血压和短指综合征有关。与人 PDE3A（磷酸二酯酶 3A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including oocyte maturation; positive regulation of oocyte development; and regulation of meiotic nuclear division. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]

Pde3a 基因产物(1)

mRNA Protein Name
NM_018779.2 NP_061249.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
11420239 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of oocyte development IGI
IGI: 通过遗传相互作用推断
19474061 MGI
acts upstream of or within oocyte maturation IDA
IDA: 通过直接分析推断
11420239 MGI
acts upstream of or within positive regulation of oocyte development IGI
IGI: 通过遗传相互作用推断
19474061 MGI
acts upstream of or within regulation of meiotic nuclear division IDA
IDA: 通过直接分析推断
11420239 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
11420239 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23008439 MGI
located in membrane IDA
IDA: 通过直接分析推断
23008439 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde3a 蛋白结构

PDEase_I

PDEase_I: pfam00233 (750 - 1011)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1141 a.a.
蛋白主名 其他名称

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

CGI-PDE A

cGMP-inhibited phosphodiesterase

cyclic GMP-inhibited phosphodiesterase A

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-U00186 K134 Inhibitor 99.84% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101312 Cilostamide Inhibitor 99.64% 否
HY-W028690 DNMDP Inhibitor 98.95% 否
HY-100530C Sp-cAMPS sodium salt 99.45% 否
HY-136350 BRD9500 Modulator 99.46% 否
HY-122751 (R)-DNMDP Inhibitor 99.59% 否
HY-100530B Sp-cAMPS / 否
HY-136350B (S)-BRD9500 99.67% 否
HY-162730 OPB-171775 Inhibitor 99.80% 否
HY-110005 Sp-cAMPS triethylamine / 否
HY-153802 Antitumor agent-100 Inducer / 否
HY-153802A Antitumor agent-100 hydrochloride Inducer / 否
HY-N10149 Nauclefine / 否
HY-N11965 4'-Methoxyisoagarotetrol Inhibitor / 否
HY-RS10216 PDE3A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10217 Pde3a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10218 Pde3a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde3a NCBI NCBI:5139
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