2. Gene
  3. RRN3 - RRN3 homolog, RNA polymerase I transcription factor Gene

RRN3 - RRN3 homolog, RNA polymerase I transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RRN3 同系物，RNA 聚合酶 I 转录因子

种属: Homo sapiens

同用名: TIFIA; A-270G1.2

基因 ID: 54700 | 基因类型: protein coding

关于 RRN3

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:15,060,022-15,094,335 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 208 orthologues. Ubiquitous expression in bone marrow (RPKM 15.3), thyroid (RPKM 14.8) and 25 other tissues.

功能概要

启用 RNA 聚合酶 I 核心启动子序列特异性 DNA 结合活性。预测参与从 RNA 聚合酶 I 启动子开始的转录。预计在几个过程的上游或内部起作用，包括 DNA 模板转录、启动； p53 类介质对内在凋亡信号通路的负调控；和转录调控，DNA 模板化。位于核仁。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in transcription initiation from RNA polymerase I promoter. Predicted to act upstream of or within several processes, including DNA-templated transcription, initiation; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

RRN3 基因产物(2)

mRNA Protein Name
NM_001301064.1 NP_001287993.1 RNA polymerase I-specific transcription initiation factor RRN3 isoform 2
NM_018427.5 NP_060897.3 RNA polymerase I-specific transcription initiation factor RRN3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase I core promoter sequence-specific DNA binding IDA
IDA: 通过直接分析推断
22368283 GOA
enables RNA polymerase I general transcription initiation factor activity IDA
IDA: 通过直接分析推断
11250903 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11250903 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in transcription initiation at RNA polymerase I promoter IDA
IDA: 通过直接分析推断
11250903 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
28334682 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RRN3 蛋白结构

RRN3

RRN3: RNA polymerase I specific transcription initiation factor RRN3 (54 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
蛋白主名 其他名称

RNA polymerase I-specific transcription initiation factor RRN3

RRN3 RNA polymerase I transcription factor homolog

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12288 RRN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RRN3 RGD RGD:1305001
Mus musculus RRN3 MGD MGI:1925255
Others RRN3 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z