MPHOSPH8 - M-phase phosphoprotein 8 Gene

中文名称：M 期磷蛋白 8

种属: Homo sapiens

同用名: TWA3; mpp8; HSMPP8

基因 ID: 54737 | 基因类型: protein coding

关于 MPHOSPH8

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,633,659-19,673,441 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 20.0), spleen (RPKM 15.8) and 25 other tissues.

功能概要

启用染色质结合活性和甲基化组蛋白结合活性。通过双链 DNA 中间体参与单链病毒 RNA 复制的负调控； DNA 甲基化的调节；和基因表达的调控。位于几种细胞成分中，包括细胞质；异染色质；和核腔。核小体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and methylated histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; regulation of DNA methylation; and regulation of gene expression. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

MPHOSPH8 基因产物(1)

mRNA	Protein	Name
NM_017520.4	NP_059990.2	M-phase phosphoprotein 8

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	29211708	GOA
enables histone reader activity	IDA IDA: 通过直接分析推断	20871592	GOA
enables methylated histone binding	IDA IDA: 通过直接分析推断	20871592	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20871592	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: 通过突变表型推断	20871592	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: 通过直接分析推断	26022416	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: 通过突变表型推断	29211708	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: 通过直接分析推断	28581500	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	8885239	GOA
located in heterochromatin	IDA IDA: 通过直接分析推断	20871592	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	20871592	GOA
located in nucleus	IDA IDA: 通过直接分析推断	8885239	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MPHOSPH8 蛋白结构

Chromo

Ank_2

Ank

0
200
400
600
800
860 a.a.

蛋白主名

其他名称

M-phase phosphoprotein 8

M-phase phosphoprotein, mpp

MPHOSPH8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MPHOSPH8	Q99549	EHMT1	Homo sapiens	Q9H9B1	Anti Tag CoIP	26496610
种属内	MPHOSPH8	Q99549	EHMT1	Homo sapiens	Q9H9B1	Anti Bait CoIP	20871592
种属内	MPHOSPH8	Q99549	SETDB1	Homo sapiens	Q15047	Anti Bait CoIP	20871592
种属内	MPHOSPH8	Q99549	H3C1	Homo sapiens	P68431	Protein Array	20871592

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08612	MPHOSPH8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MPHOSPH8	VGNC	VGNC:31575
Mus musculus	MPHOSPH8	MGD	MGI:1922589
Rattus norvegicus	MPHOSPH8	RGD	RGD:1305133
Macaca mulatta	MPHOSPH8	VGNC	VGNC:74864
Felis catus	MPHOSPH8	VGNC	VGNC:63571

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MPHOSPH8 - M-phase phosphoprotein 8 Gene

关于 MPHOSPH8

功能概要

MPHOSPH8 基因产物(1)

MPHOSPH8 蛋白结构

MPHOSPH8 蛋白互作信息

关联疾病

直系同源

热门区域

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MPHOSPH8 - M-phase phosphoprotein 8 Gene

关于 MPHOSPH8

功能概要

MPHOSPH8 基因产物(1)

MPHOSPH8 蛋白结构

MPHOSPH8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z