ALKBH5 - alkB homolog 5, RNA demethylase Gene

中文名称：alkB 同系物 5，RNA 去甲基化酶

种属: Homo sapiens

同用名: ABH5; OFOXD; OFOXD1

基因 ID: 54890 | 基因类型: protein coding

关于 ALKBH5

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,183,828-18,209,954 (from NCBI)

This gene has 3 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 46.1), heart (RPKM 30.6) and 25 other tissues.

功能概要

启用 mRNA N6-甲基腺苷双加氧酶活性。参与 RNA 代谢过程；从细胞核输出 mRNA；和对缺氧的反应。位于高尔基体；胞质溶胶；和核斑点。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH5 基因产物(1)

mRNA	Protein	Name
NM_017758.4	NP_060228.3	RNA demethylase ALKBH5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 2-oxoglutarate-dependent dioxygenase activity	IDA IDA: 通过直接分析推断	21264265	GOA
enables mRNA N6-methyladenosine dioxygenase activity	IDA IDA: 通过直接分析推断	23177736	GOA
enables molecular condensate scaffold activity	IDA IDA: 通过直接分析推断	37474102	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA destabilization	IDA IDA: 通过直接分析推断	34048572	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: 通过直接分析推断	37474102	GOA
acts upstream of or within regulation of mRNA export from nucleus	IMP IMP: 通过突变表型推断	23177736	GOA
acts upstream of or within regulation of mRNA processing	IMP IMP: 通过突变表型推断	23177736	GOA
involved in regulation of translation	IDA IDA: 通过直接分析推断	36944332	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	21264265	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nuclear speck	IDA IDA: 通过直接分析推断	23177736	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21264265	GOA
is active in paraspeckles	IDA IDA: 通过直接分析推断	37474102	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALKBH5 蛋白结构

2OG-FeII_Oxy_2

0
100
200
300
394 a.a.

蛋白主名

其他名称

RNA demethylase ALKBH5

AlkB family member 5, RNA demethylase

关联疾病

疾病名称

别名

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12304	IOX1	Inhibitor	99.72%	否
HY-155489	DDO-2728		98.55%	否
HY-RS00606	ALKBH5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-148933	ALKBH5-IN-2		/	否
HY-165422	ALKBH5-IN-3		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ALKBH5	RGD	RGD:1309496
Macaca mulatta	ALKBH5	VGNC	VGNC:103786
Bos taurus	ALKBH5	VGNC	VGNC:25836
Canis familiaris	ALKBH5	VGNC	VGNC:53262
Felis catus	ALKBH5	VGNC	VGNC:98758
Mus musculus	ALKBH5	MGD	MGI:2144489

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ALKBH5 - alkB homolog 5, RNA demethylase Gene

关于 ALKBH5

功能概要

ALKBH5 基因产物(1)

ALKBH5 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

ALKBH5 - alkB homolog 5, RNA demethylase Gene

关于 ALKBH5

功能概要

ALKBH5 基因产物(1)

ALKBH5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z