2. Gene
  3. NCAPG2 - non-SMC condensin II complex subunit G2 Gene

NCAPG2 - non-SMC condensin II complex subunit G2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：非 SMC 凝聚素 II 复合亚基 G2

种属: Homo sapiens

同用名: 3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2

基因 ID: 54892 | 基因类型: protein coding

关于 NCAPG2

Cytogenetic location: 7q36.3 Genomic coordinates (GRCh38): 7:158,631,169-158,704,804 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues.

功能概要

该基因编码的蛋白质属于 Condensin2nSMC 蛋白质家族。编码的蛋白质是凝缩蛋白 II 复合物的调节亚基，它与凝缩蛋白 I 复合物一起在有丝分裂期间的染色体组装和分离中发挥作用。胚胎的早期发育需要小鼠体内的一种类似蛋白质。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

NCAPG2 基因产物(3)

mRNA Protein Name
NM_001281932.2 NP_001268861.1 condensin-2 complex subunit G2 isoform a
NM_001281933.2 NP_001268862.1 condensin-2 complex subunit G2 isoform b
NM_017760.7 NP_060230.5 condensin-2 complex subunit G2 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables methylated histone binding IDA
IDA: 通过直接分析推断
20622854 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17268547 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCAPG2 蛋白结构

Condensin2nSMC

Condensin2nSMC: Condensin II non structural maintenance of chromosomes subunit (210 - 363)

Condensin2nSMC

Condensin2nSMC: Condensin II non structural maintenance of chromosomes subunit (673 - 827)

  • 0
  • 200
  • 400
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  • 1000
  • 1143 a.a.
蛋白主名 其他名称

condensin-2 complex subunit G2

chromosome-associated protein G2

关联疾病

疾病名称 别名
Khan-Khan-Katsanis Syndrome

3KS

3k Syndrome
Peters-Plus Syndrome

Krause-Kivlin Syndrome

Peters Plus Syndrome

Peters Anomaly

Irido-Corneo-Trabecular Dysgenesis

PTRPLS

Peters Anomaly With Short-Limb Dwarfism

Peters Anomaly-Short Limb Dwarfism Syndrome

Peters Anomaly With Short Limb Dwarfism

Peters Congenital Glaucoma

Krause-Van Schooneveld-Kivlin Syndrome

Peters' Plus Syndrome

Peters'-Plus Syndrome

Anomaly Peters
Primary Microcephaly

True Microcephaly

Microcephaly, Primary
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09069 NCAPG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NCAPG2 VGNC VGNC:63733
Macaca mulatta NCAPG2 VGNC VGNC:75003
Bos taurus NCAPG2 VGNC VGNC:31904
Rattus norvegicus NCAPG2 RGD RGD:1308406
Mus musculus NCAPG2 MGD MGI:1923294
Canis familiaris NCAPG2 VGNC VGNC:43642
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