OXSM - 3-oxoacyl-ACP synthase, mitochondrial Gene

中文名称：3-oxoacyl-ACP 合酶，线粒体

种属: Homo sapiens

同用名: KS; CEM1; KASI; FASN2D

基因 ID: 54995 | 基因类型: protein coding

关于 OXSM

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:25,790,090-25,794,531 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 3.3), thyroid (RPKM 1.6) and 25 other tissues.

功能概要

该基因编码一种β-酮脂酰合成酶。所编码的酶是线粒体中脂肪酸链延长所必需的。已经描述了可变剪接的转录变体。[RefSeq 提供，2009 年 2 月]

This gene encodes a beta-ketoacyl synthetase. The encoded Enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

OXSM 基因产物(2)

mRNA	Protein	Name
NM_001145391.2	NP_001138863.1	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 2 precursor
NM_017897.3	NP_060367.1	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity	IDA IDA: 通过直接分析推断	15668256	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in acyl-CoA metabolic process	IDA IDA: 通过直接分析推断	15668256	GOA
involved in medium-chain fatty acid biosynthetic process	IDA IDA: 通过直接分析推断	15668256	GOA
involved in short-chain fatty acid biosynthetic process	IDA IDA: 通过直接分析推断	15668256	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrion	IMP IMP: 通过突变表型推断	15668256	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OXSM 蛋白结构

ketoacyl-synt

Ketoacyl-synt_C

0
100
200
300
400
459 a.a.

蛋白主名

其他名称

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

3-ketoacyl-acyl carrier protein synthase

关联疾病

疾病名称

别名

Animal Phobia

Zoophobia

Fear Of Animals

Gaucher Disease, Type Iii

Gaucher Disease, Subacute Neuronopathic Type	Gd Iii
Gaucher Disease, Chronic Neuronopathic Type	Gaucher Disease, Juvenile And Adult, Cerebral
Gaucher Disease Type 3	GD3
Gaucher'S Disease Type Iii	Gaucher Disease Type Iii
Gd 3	Cerebral Juvenile And Adult Form Of Gaucher Disease
Chronic Neuronopathic Gaucher Disease	Gaucher Disease 3
Cerebral, Juvenile And Adult, Gaucher Disease	Gaucher Disease Chronic Neuronopathic Type
Gaucher Disease Type Ii	Subacute Neuronopathic Gaucher Disease
Type 3 Gaucher Disease	Gaucher Disease, Type 3
Gaucher Disease, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09891	OXSM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	OXSM	VGNC	VGNC:32513
Canis familiaris	OXSM	VGNC	VGNC:44204
Felis catus	OXSM	VGNC	VGNC:102794
Rattus norvegicus	OXSM	RGD	RGD:1311092
Mus musculus	OXSM	MGD	MGI:1918397
Macaca mulatta	OXSM	VGNC	VGNC:75681

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